| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 31 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ZNF688 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是基于假设的3篇关于ZNF688抗体的参考文献示例(注：实际文献可能有限，建议通过学术数据库核实最新进展)：
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1. **文献名称**: "ZNF688 Functions as an Oncogenic Regulator in Hepatocellular Carcinoma"
**作者**: Li, X., Wang, Y., & Zhang, J.
**摘要**: 本研究通过免疫组化及Western blot分析，利用ZNF688特异性抗体，发现ZNF688在肝癌组织中高表达，且与患者预后不良相关。机制研究表明其通过调控Wnt/β-catenin通路促进肿瘤侵袭。
2. **文献名称**: "Genome-wide Mapping of ZNF688 Binding Sites Reveals Its Role in Transcriptional Repression"
**作者**: Chen, S., Liu, T., & Zhou, D.
**摘要**: 采用ChIP-seq技术结合ZNF688抗体，鉴定了该蛋白在基因组上的结合位点，发现其倾向于结合富含GC碱基的启动子区域，并通过招募组蛋白去乙酰化酶抑制靶基因表达。
3. **文献名称**: "ZNF688 Antibody Validation for Immunofluorescence in Neural Progenitor Cells"
**作者**: Martinez, R., & Kim, H.
**摘要**: 本文系统验证了多种ZNF688抗体的特异性，确认了某商业抗体适用于细胞核内定位的免疫荧光检测，并发现ZNF688在神经干细胞分化过程中的动态表达变化。
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**提示**：若实际文献不足，建议：
1. 检索PubMed或Google Scholar，关键词“ZNF688 antibody”;
2. 查阅抗体供应商(如Abcam、CST)的产品引用文献;
3. 关注锌指蛋白家族综述中提及ZNF688的研究。
The ZNF688 antibody is a tool used to study the ZNF688 protein, a member of the zinc finger protein family characterized by C2H2-type zinc finger domains, which facilitate DNA or RNA binding. ZNF688 is implicated in transcriptional regulation and chromatin remodeling, though its exact biological roles remain less characterized compared to other zinc finger proteins. It is ubiquitously expressed, with higher levels observed in tissues like the liver, kidney, and immune cells. Research suggests potential involvement in cancer pathways, particularly through interactions with tumor suppressors or oncogenic complexes, though mechanistic insights are limited.
ZNF688 antibodies are typically developed in hosts such as rabbits or mice, targeting specific epitopes within its N-terminal or zinc finger regions. These antibodies are essential for applications like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to map DNA-binding sites or protein interactions. Validation often includes knockout cell lines to confirm specificity. Despite its emerging relevance, ZNF688's functional diversity and regulatory networks require further exploration. Current studies focus on its role in cellular stress responses, differentiation, and possible contributions to malignancies like hepatocellular carcinoma or leukemia, highlighting its potential as a biomarker or therapeutic target.
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