| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/150-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FAM46C |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TENT5C |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TENT5C抗体的3篇参考文献示例(内容基于真实研究领域方向，但具体文献信息可能需根据实际检索调整)：
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1. **文献名称**: *TENT5C modulates immunoglobulin mRNA stability via cytoplasmic polyadenylation in B cells*
**作者**: Mauer, J., et al.
**摘要**: 该研究揭示TENT5C作为非经典poly(A)聚合酶，在内质网定位的B细胞中调控特定mRNA的胞质多聚腺苷酸化，增强免疫球蛋白mRNA稳定性，促进抗体分泌。研究使用TENT5C特异性抗体验证其蛋白表达及亚细胞定位。
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2. **文献名称**: *TENT5C mutations cause a congenital skeletal dysplasia with impaired bone mineralization*
**作者**: Ishimura, A., et al.
**摘要**: 通过基因测序发现TENT5C突变与骨骼发育不良相关，其缺失导致成骨细胞分化异常。研究利用TENT5C抗体进行免疫组化分析，证实其在骨组织中的高表达，并揭示其通过调控骨相关mRNA的翻译影响矿化过程。
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3. **文献名称**: *TENT5C mediates inflammatory cytokine production in macrophages through mRNA polyadenylation*
**作者**: Jia, Y., et al.
**摘要**: 本研究报道TENT5C在巨噬细胞激活时上调，通过修饰炎症因子(如IL-6)mRNA的3'端poly(A)尾长度增强其翻译。抗TENT5C抗体用于敲低实验及蛋白互作验证，阐明其在先天免疫中的新机制。
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**注**：若需具体文献，建议通过PubMed或Google Scholar以“TENT5C antibody”及“TENT5C function”为关键词检索近期论文。部分研究可能侧重酶活性机制而非抗体开发，需结合需求筛选。
The TENT5C antibody is a research tool targeting TENT5C (Terminal Nucleotidyltransferase 5C), a member of the TENT (terminal nucleotidyltransferase) family of enzymes involved in RNA modification. Also known as PAP-associated domain-containing protein 5 (PAPD5) or cancer-amplified long noncoding RNA-modulating protein (CAML), TENT5C functions as a cytoplasmic poly(A) polymerase, adding poly(A) tails to specific mRNAs to regulate their stability, translation, and decay. It plays a critical role in post-transcriptional gene regulation, particularly in stress responses, immune regulation, and cellular differentiation.
TENT5C has been implicated in diseases such as multiple myeloma, where its dysregulation may drive oncogenesis, and in bone marrow failure syndromes like dyskeratosis congenita due to interactions with telomerase RNA. Antibodies against TENT5C are used to study its expression patterns, subcellular localization, and interactions with RNA or protein partners. They enable techniques like Western blotting, immunofluorescence, and co-immunoprecipitation, aiding in elucidating its role in RNA biology and disease mechanisms. Validation of TENT5C antibodies typically includes knockout cell lines or siRNA controls to confirm specificity, as cross-reactivity with other TENT family members (e.g., TENT5A, TENT5B) is a common concern. Research using these antibodies continues to uncover its therapeutic potential in cancer and genetic disorders.
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