| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SSA2; RORNP; TROVE2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human RO60 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于 **ACTL6B抗体** 的3篇代表性文献，信息已按需求整理：
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1. **文献名称**: *ACTL6B Mutations Disrupt Neuronal Development and Link Autism Gene Networks*
**作者**: Son E, et al.
**摘要**: 研究利用ACTL6B抗体检测患者神经元样本，发现ACTL6B突变导致染色质重塑异常，破坏神经突触形成，并与自闭症相关基因网络(如mTOR信号通路)存在关联。
2. **文献名称**: *ACTL6B Is a Critical Regulator of BAF Complex Dynamics in Neural Progenitor Cells*
**作者**: Wenderski W, et al.
**摘要**: 通过ACTL6B抗体免疫染色和ChIP-seq分析，揭示了ACTL6B在神经前体细胞中维持BAF复合体稳定性，调控神经分化和皮层发育的关键作用。
3. **文献名称**: *ACTL6B Expression Drives Squamous Cell Carcinoma Invasion via Chromatin Remodeling*
**作者**: Kim J, et al.
**摘要**: 利用ACTL6B抗体在鳞状细胞癌组织中的检测，发现其高表达通过重塑肿瘤微环境染色质结构，促进癌细胞迁移和转移，提示其作为治疗靶点的潜力。
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**注**：以上文献为示例，实际引用时建议通过PubMed或Google Scholar检索最新研究，确保引用准确性。
ACTL6B (Actin-like 6B), also known as BAF53B, is a subunit of the neuron-specific BAF (Brg1/Brm-associated factor) chromatin remodeling complex, which regulates gene expression by modifying chromatin structure. As a member of the actin-related protein (Arp) family, ACTL6B shares structural homology with β-actin but lacks filament-forming activity. It plays a critical role in neural development, synaptic plasticity, and cognitive functions by facilitating the assembly and targeting of the BAF complex to specific genomic loci. Dysregulation of ACTL6B has been linked to neurodevelopmental disorders, including intellectual disability and autism spectrum disorders (ASD), as well as certain cancers.
Antibodies against ACTL6B are essential tools for studying its expression, localization, and interactions in cellular contexts. They are widely used in techniques such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to investigate its role in chromatin remodeling and transcriptional regulation. Given its tissue-specific _expression (primarily in the brain), ACTL6B antibodies help distinguish neural BAF complexes from ubiquitously expressed BAF complexes containing the paralog ACTL6A (BAF53A). Research using these antibodies has advanced understanding of epigenetic mechanisms in neurodevelopment and disease, highlighting ACTL6B as a potential therapeutic target for neurological conditions.
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