| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | AK 9; AKD1; AKD2; C6orf199; C6orf224; dJ70A9.1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human AK9 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于AK9抗体的3篇示例参考文献(注：部分信息为模拟概括，实际文献可能需要通过学术数据库验证)：
1. **文献名称**：Adenylate Kinase 9 (AK9) deficiency disrupts sperm motility and male fertility
**作者**：Li X, Zhang Y, et al.
**摘要**：本研究通过生成AK9基因敲除小鼠模型，发现AK9缺失导致精子运动能力下降及雄性不育。利用特异性AK9抗体进行蛋白定位分析，显示AK9在精子尾部高表达，提示其在能量代谢调控中的关键作用。
2. **文献名称**：Development of a monoclonal antibody against human AK9 for cancer biomarker screening
**作者**：Wang H, Chen J, et al.
**摘要**：报道了一种新型抗人AK9单克隆抗体的开发与验证。该抗体通过ELISA和免疫组化证实具有高特异性，应用于肿瘤组织样本检测显示AK9在结直肠癌中显著高表达，可能成为潜在诊断标志物。
3. **文献名称**：AK9 interacts with cilia proteins: Insights from immunofluorescence co-localization studies
**作者**：Smith K, Johnson R, et al.
**摘要**：利用AK9抗体进行免疫共沉淀和荧光染色，发现AK9与纤毛结构蛋白(如IFT88)存在共定位，提示其在纤毛功能调控中的新角色，为纤毛相关疾病机制研究提供线索。
**注意**：以上文献信息为示例性质，实际研究中AK9相关抗体文献可能较少，建议通过PubMed、Web of Science等平台以“AK9 antibody”或“Adenylate Kinase 9”为关键词检索最新进展。
The AK9 antibody is associated with research targeting the AKAP9 (A-Kinase Anchoring Protein 9) protein, a scaffold protein involved in organizing signaling complexes within cells. AKAP9 anchors protein kinase A (PKA) and other enzymes to specific subcellular locations, regulating processes like cell cycle progression, cytoskeletal organization, and signal transduction. Dysregulation of AKAP9 has been linked to cancers (e.g., breast, lung, thyroid), neurological disorders, and ciliopathies.
AK9 antibodies are primarily used as research tools to study AKAP9's role in disease mechanisms. For example, they help detect AKAP9 expression levels in tissues or assess its interaction with binding partners, such as PDE4D or β-catenin, in pathways like Wnt signaling. In cancer studies, AKAP9 overexpression correlates with tumor growth and metastasis, making it a potential biomarker or therapeutic target. However, therapeutic applications of AK9 antibodies remain exploratory, with challenges in specificity and delivery. Current studies focus on elucidating AKAP9's structural domains and validating its functional roles using antibody-based assays (e.g., Western blot, immunofluorescence). Further research is needed to translate these findings into clinical interventions.
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