| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FPS; FPPS; POROK9 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human FDPS |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FDPS抗体的3篇代表性文献摘要信息(注：文献为示例性概括，非真实引用)：
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1. **文献名称**：*FDPS as a therapeutic target in multiple myeloma: Functional characterization of a novel monoclonal antibody*
**作者**：Li Y, et al.
**摘要**：研究开发了针对FDPS蛋白的单克隆抗体，验证了其在多发性骨髓瘤细胞系中的特异性结合能力。抗体成功用于Western blot和免疫荧光实验，揭示了FDPS高表达与骨髓瘤细胞增殖及药物耐药性的相关性，为靶向治疗提供工具支持。
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2. **文献名称**：*Immunohistochemical analysis of FDPS expression in osteoporotic bone tissue using a novel polyclonal antibody*
**作者**：Garcia-Ruiz C, et al.
**摘要**：团队制备了兔源多克隆FDPS抗体，并通过免疫组化检测骨质疏松患者骨组织中FDPS的表达水平。结果显示FDPS在成骨细胞中的异常高表达与骨密度下降相关，提示其可作为骨代谢疾病的潜在生物标志物。
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3. **文献名称**：*Development of FDPS-specific antibodies for detecting statin-induced enzyme inhibition in hepatic cells*
**作者**：Tanaka M, et al.
**摘要**：研究利用FDPS抗体评估他汀类药物对肝细胞中甲羟戊酸通路的影响。通过ELISA和流式细胞术证实，药物处理后FDPS蛋白表达显著下调，抗体为代谢性疾病药物机制研究提供了可靠检测手段。
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(注：以上文献信息为模拟生成，实际引用需查询PubMed等数据库获取真实文献。)
**Background of FDPS Antibody**
Farnesyl Diphosphate Synthase (FDPS) is a key enzyme in the mevalonate pathway, catalyzing the synthesis of farnesyl diphosphate (FPP), a precursor for cholesterol, steroid hormones, and lipid-modified proteins. FDPS plays a critical role in cellular processes, including membrane integrity, protein prenylation, and signaling pathways. Dysregulation of FDPS is linked to diseases such as cancer, osteoporosis, and metabolic disorders, making it a therapeutic target. For instance, nitrogen-containing bisphosphonates (N-BPs), drugs used to treat bone resorption in osteoporosis and metastatic bone disease, inhibit FDPS to disrupt osteoclast function.
FDPS antibodies are essential tools for studying the enzyme's expression, localization, and function in various tissues and disease models. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to quantify FDPS levels in cancer cells, bone tissue, or metabolic studies. Researchers also employ these antibodies to explore FDPS's role in drug resistance mechanisms, particularly in cancers treated with bisphosphonates or statins. Additionally, FDPS antibodies aid in validating the efficacy of emerging therapies targeting the mevalonate pathway. Their specificity and reliability are crucial for understanding FDPS-related disease mechanisms and advancing translational research.
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