Rabbit Polyclonal MFAP2 Antibody

MFAP2 (Microfibrillar-associated protein 2) is a secreted extracellular matrix protein primarily associated with microfibrils, such as those containing fibrillin-1. which are critical for elastic fiber assembly and tissue integrity. It plays a role in cell adhesion, connective tissue development, and modulating TGF-β signaling. MFAP2 is implicated in cardiovascular, skeletal, and ocular disorders, particularly Marfan syndrome and other fibrillinopathies, due to its interaction with fibrillin-rich structures. Antibodies targeting MFAP2 are valuable tools in research to study its expression, localization, and function in tissues. They are used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize MFAP2 distribution in elastic fibers or assess its dysregulation in disease models. Some studies also explore MFAP2's potential as a biomarker in cancer or fibrosis, given its altered expression in certain tumors and fibrotic tissues. Commercial MFAP2 antibodies are typically raised in rabbits or mice, with validation in human and murine specimens. However, specificity challenges may arise due to homology with other microfibril-associated proteins. Ongoing research aims to clarify MFAP2's precise mechanistic roles and therapeutic relevance.