| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SLMO2; C20orf45; dJ543J19.5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PRELID3B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PRELID3B抗体的3篇参考文献示例(基于公开信息整理，文献标题和作者为虚拟示例，建议通过PubMed或Google Scholar核实具体文献)：
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1. **标题**: "PRELID3B regulates mitochondrial apoptosis through interaction with 14-3-3 proteins"
**作者**: Smith A, et al.
**摘要**: 本研究揭示了PRELID3B在调控线粒体依赖性细胞凋亡中的作用，利用特异性抗体证实其通过与14-3-3蛋白的相互作用调控BAX/BAK依赖性凋亡通路。
2. **标题**: "Expression and functional analysis of PRELID3B in colorectal cancer progression"
**作者**: Lee H, et al.
**摘要**: 通过免疫组化(使用抗人PRELID3B抗体)发现PRELID3B在结直肠癌组织中高表达，且与患者预后不良相关，进一步功能实验表明其通过ROS信号促进肿瘤侵袭。
3. **标题**: "Structural insights into PRELID3B-TRIAP1 complex in mitochondrial lipid transport"
**作者**: Zhang Y, et al.
**摘要**: 利用抗PRELID3B抗体进行免疫共沉淀实验，解析了PRELID3B与TRIAP1形成的复合物结构，并证明其在线粒体磷脂转运及膜稳定性中的关键作用。
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**注意**：以上为模拟文献，实际文献需通过学术数据库检索。建议以关键词“PRELID3B antibody”、“PRELID3B function”或结合具体研究领域(如癌症、线粒体)进行查询。
The PRELID3B (PRELI Domain-Containing Protein 3B) antibody is a tool used to detect and study the PRELID3B protein, a member of the PRELI family involved in mitochondrial function. PRELID3B is localized to mitochondria and plays a role in maintaining mitochondrial membrane integrity, lipid transport, and apoptosis regulation. It interacts with other mitochondrial proteins, such as TRIAP1. to modulate cardiolipin synthesis, a lipid critical for mitochondrial dynamics and cellular energy metabolism. Dysregulation of PRELID3B has been linked to mitochondrial disorders, cancer, and neurodegenerative diseases, making it a focus of pathophysiological research.
The PRELID3B antibody enables researchers to investigate the protein's expression, localization, and interactions via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It is particularly valuable in studies exploring mitochondrial dysfunction, metabolic reprogramming in cancer, or cell death pathways. Commercial PRELID3B antibodies are typically produced in hosts like rabbits or mice, validated for specificity using knockout controls or siRNA silencing. Research utilizing this antibody has highlighted PRELID3B's role in balancing mitochondrial homeostasis, influencing cellular responses to stress, and its potential as a therapeutic target. Ongoing studies aim to clarify its mechanisms in disease contexts, emphasizing its importance in mitochondrial biology and pathology.
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