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Rabbit Polyclonal RPL18 Antibody

  • 中文名: RPL18抗体
  • 别    名: L18
货号: IPDX10284
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesL18
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human RPL18
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于RPL18抗体的模拟参考文献示例(仅供学术参考,具体文献需通过数据库检索获取):

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1. **标题**: *RPL18 as a novel biomarker in hepatocellular carcinoma: Immunohistochemical analysis*

**作者**: Zhang Y, et al.

**摘要**: 研究通过RPL18抗体进行免疫组化(IHC),发现RPL18在肝癌组织中显著高表达,且与患者预后不良相关,提示其可能作为肝癌诊断或治疗的潜在靶点。

2. **标题**: *Characterization of RPL18 antibody for ribosome profiling in translational regulation*

**作者**: Lee S, et al.

**摘要**: 验证RPL18抗体的特异性,并应用于核糖体分离和翻译组学分析,揭示RPL18在应激条件下调控mRNA选择性翻译的分子机制。

3. **标题**: *Evaluation of RPL18 as a housekeeping gene control in Western blotting*

**作者**: Smith J, et al.

**摘要**: 在不同细胞系中测试RPL18抗体的稳定性,证实其在非应激条件下可作为可靠的内参蛋白,优于传统β-actin和GAPDH。

4. **标题**: *RPL18 interacts with viral RNA to promote viral replication: Evidence from co-immunoprecipitation*

**作者**: Chen L, et al.

**摘要**: 利用RPL18抗体进行免疫共沉淀(Co-IP),发现RPL18与多种RNA病毒基因组直接结合,敲低RPL18显著抑制病毒复制,提示其抗病毒治疗潜力。

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**建议**:如需真实文献,可通过PubMed或Google Scholar检索关键词(如“RPL18 antibody”、“ribosomal protein L18 application”),并筛选近年的研究或经典高引论文。

背景信息

The RPL18 antibody targets ribosomal protein L18 (RPL18), a component of the 60S large subunit of eukaryotic ribosomes. RPL18 plays a critical role in ribosome assembly, stability, and translation by facilitating rRNA binding and peptide bond formation during protein synthesis. As part of the conserved ribosomal protein family, RPL18 is essential for cellular proliferation and homeostasis. Antibodies against RPL18 are widely used in research to study ribosome biogenesis, translational regulation, and their dysregulation in diseases. For example, altered RPL18 expression has been linked to cancers, developmental disorders, and neurodegenerative conditions, making it a biomarker of interest. These antibodies are validated for techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect RPL18's localization (primarily nucleoli and cytoplasm) and expression levels. Studies also utilize RPL18 antibodies to explore ribosomopathies, where defective ribosome assembly triggers cellular stress pathways. Available as monoclonal or polyclonal variants from multiple host species, RPL18 antibodies are critical tools for dissecting the molecular interplay between ribosome dysfunction and disease mechanisms.

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