| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MRPS35; HSPC007; MRP-S28; MRP-S35 |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human MRPS28 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MRPS28抗体的3篇参考文献示例(注：以下内容为模拟虚构，仅供参考格式)：
1. **文献名称**: *Mitochondrial ribosomal protein S28 antibody validation in hepatocellular carcinoma*
**作者**: Wang, L. et al.
**摘要**: 本研究验证了一种高特异性的MRPS28多克隆抗体，通过免疫印迹和免疫组化技术，发现MRPS28在肝癌组织中的表达显著高于正常肝组织，提示其可能作为肝癌诊断的潜在生物标志物。
2. **文献名称**: *Role of MRPS28 in mitochondrial dysfunction: Insights from antibody-based knockdown assays*
**作者**: Gonzalez, S. & Patel, R.
**摘要**: 利用MRPS28抗体进行蛋白质敲低实验，发现MRPS28缺失会导致线粒体呼吸链复合物活性下降，表明其在维持线粒体功能中起关键作用，并与神经退行性疾病相关。
3. **文献名称**: *Development of a monoclonal antibody against MRPS28 for mitochondrial proteomics studies*
**作者**: Kim, J. et al.
**摘要**: 报道了一种新型MRPS28单克隆抗体的开发，通过质谱和免疫荧光验证其特异性，并应用于线粒体蛋白质组学分析，揭示了MRPS28在不同细胞类型中的亚定位差异。
(注：若需真实文献，建议通过PubMed或Google Scholar以“MRPS28 antibody”为关键词检索。)
The MRPS28 antibody is a tool used to detect mitochondrial ribosomal protein S28 (MRPS28), a component of the small subunit (28S) of the mitochondrial ribosome. Mitochondrial ribosomes are essential for translating mitochondrial DNA-encoded mRNAs, producing proteins critical for oxidative phosphorylation (OXPHOS) and cellular energy metabolism. MRPS28 plays a structural or functional role in ribosome assembly, ensuring proper synthesis of electron transport chain (ETC) complexes. Dysregulation of mitochondrial ribosomal proteins, including MRPS28. is linked to mitochondrial disorders, cancer, and neurodegenerative diseases.
Antibodies against MRPS28 enable researchers to study its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunohistochemistry. These studies help elucidate its role in mitochondrial dysfunction and disease mechanisms. For example, reduced MRPS28 levels may impair mitochondrial translation, leading to ETC deficiencies and metabolic stress. In cancer, altered MRPS28 expression has been observed in certain tumors, suggesting potential as a biomarker or therapeutic target.
Commercial MRPS28 antibodies are typically validated for specificity across human and model organisms, supporting research in mitochondrial biology and pathology. Understanding MRPS28's function contributes to insights into cellular energy regulation and disease pathways involving mitochondrial protein synthesis.
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