首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal PAFAH1B3 Antibody

  • 中文名: PAFAH1B3抗体
  • 别    名: PAFAHG
货号: IPDX10320
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是关于PAFAH1B3抗体的3篇参考文献示例(注:文献为虚构示例,实际引用需核实):

---

1. **文献名称**:*PAFAH1B3 promotes ovarian cancer progression via lipid metabolism regulation*

**作者**:Li, X., Wang, Y., & Chen, Q.

**摘要**:本研究通过免疫组化(使用PAFAH1B3特异性抗体)发现PAFAH1B3在卵巢癌组织中高表达,且与患者不良预后相关。机制研究表明,PAFAH1B3通过调节脂质代谢促进肿瘤细胞增殖和转移。

2. **文献名称**:*Development of a monoclonal antibody against PAFAH1B3 for biomarker detection in colorectal cancer*

**作者**:Zhang, H., Liu, R., & Kim, S.

**摘要**:文章报道了一种新型抗PAFAH1B3单克隆抗体的开发,并验证其在结直肠癌组织中的特异性。通过Western blot和免疫荧光证实,PAFAH1B3在癌变组织中表达上调,可作为潜在诊断标志物。

3. **文献名称**:*PAFAH1B3 interacts with oncogenic kinases to drive tumorigenesis in pancreatic cancer*

**作者**:Garcia, M., Patel, A., & Nguyen, T.

**摘要**:利用PAFAH1B3抗体进行免疫共沉淀实验,揭示了PAFAH1B3与多种激酶(如AKT和ERK)的相互作用,促进胰腺癌细胞的存活和耐药性,提示其作为治疗靶点的潜力。

---

如需真实文献,建议通过PubMed或Google Scholar搜索关键词“PAFAH1B3 antibody”、“PAFAH1B3 cancer”等获取最新研究。

背景信息

The PAFAH1B3 antibody is designed to detect PAFAH1B3 (Platelet-Activating Factor Acetylhydrolase 1B3), a subunit of the intracellular type I PAF-AH enzyme complex. This enzyme hydrolyzes platelet-activating factor (PAF) and related phospholipids, regulating inflammatory responses and lipid metabolism. PAFAH1B3. encoded by the PAFAH1B3 gene on chromosome 19. forms heterotrimers with PAFAH1B2 and the catalytic alpha subunit PAFAH1B1 (also known as LIS1). While PAFAH1B1 is linked to neuronal migration and lissencephaly, PAFAH1B3's role extends beyond neural development. Recent studies highlight its overexpression in cancers, including ovarian, breast, and hepatocellular carcinoma, where it promotes tumor growth, metastasis, and chemoresistance by modulating lipid signaling and metabolic pathways. The PAFAH1B3 antibody is widely used in Western blotting, immunohistochemistry, and immunofluorescence to study its expression patterns, subcellular localization, and pathological relevance. Its applications span cancer research, neurobiology, and inflammation studies, offering insights into disease mechanisms and potential therapeutic targets. Researchers also explore PAFAH1B3 as a biomarker for prognosis and treatment response in oncology. Commercial antibodies are typically validated for specificity against recombinant human PAFAH1B3. ensuring reliability in experimental models.

客户数据及评论

折叠内容

大包装询价

×