Rabbit Polyclonal SPSB2 Antibody

The SPSB2 (SPRY domain-containing SOCS box protein 2) antibody targets a protein belonging to the SPSB family, which functions as part of the ubiquitin-proteasome system. SPSB2 contains a SPRY domain for specific protein-protein interactions and a SOCS box motif that recruits E3 ubiquitin ligase complexes, facilitating substrate ubiquitination and degradation. It plays a regulatory role in cellular processes such as cytokine signaling, apoptosis, and nitric oxide production by binding to partners like inducible nitric oxide synthase (iNOS). Research links SPSB2 to diseases, including cancer, viral infections, and inflammatory disorders, where its dysregulation may influence disease progression. The SPSB2 antibody is widely used in molecular biology techniques (e.g., Western blot, immunoprecipitation) to study protein expression, interaction networks, and post-translational modifications. It helps elucidate SPSB2’s mechanistic roles in pathways like NF-κB or JAK-STAT and its potential as a therapeutic target. Commercial SPSB2 antibodies are typically validated for specificity in human, mouse, or rat models, with applications spanning basic research and drug development.