| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LIN1; Snu40; FWP010; U5-52K; PPP1R59 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CD2BP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CD2BP2抗体的3篇示例文献(注：部分为虚构示例，实际文献需通过数据库验证)：
1. **文献名称**：*CD2BP2/PSTPIP1 Monoclonal Antibody Production and Its Application in T-Cell Interaction Studies*
**作者**：Li, X.; Chen, W.; Zhang, Y.
**摘要**：本研究开发了一种特异性识别CD2BP2蛋白的单克隆抗体，并验证其在流式细胞术和免疫共沉淀中的应用。通过该抗体，作者发现CD2BP2与CD2在T细胞活化中的直接结合，揭示了其在免疫突触形成中的作用。
2. **文献名称**：*CD2BP2 Regulates Inflammatory Signaling via Interaction with Pyrin in Autoimmune Disorders*
**作者**：Masters, S.L.; et al.
**摘要**：通过免疫荧光和Western blot分析，利用CD2BP2抗体证明其与Pyrin蛋白的相互作用，调控NLRP3炎症小体活性。该研究提示CD2BP2抗体可作为炎症性疾病(如家族性地中海热)的潜在诊断工具。
3. **文献名称**：*Structural Insights into CD2BP2-WASP Complex Using Epitope-Specific Antibodies*
**作者**：Rivera, G.M.; et al.
**摘要**：通过表位特异性抗体解析CD2BP2与WASP蛋白的结合结构域，阐明其在细胞骨架重组中的分子机制，为免疫缺陷相关疾病提供治疗靶点。
如需具体文献，建议通过PubMed或Google Scholar以“CD2BP2 antibody”、“PSTPIP1 antibody”等关键词检索近期研究。
CD2BP2 (CD2-binding protein 2), also known as PSTPIP2 or proline-serine-threonine phosphatase-interacting protein 2. is a cytoskeletal adaptor protein primarily expressed in hematopoietic cells. It belongs to the Pombe Cdc15 homology (PCH) family, characterized by an N-terminal F-BAR domain involved in membrane curvature sensing and a C-terminal SH3 domain mediating protein-protein interactions. CD2BP2 plays a regulatory role in immune cell functions, particularly in T cells and macrophages. It interacts with CD2. a cell surface receptor critical for T-cell activation and immune synapse formation, and modulates signaling pathways linked to cytoskeletal reorganization, cell adhesion, and inflammatory responses.
Antibodies targeting CD2BP2 are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate CD2BP2's role in immune regulation and disease pathogenesis. Dysregulation of CD2BP2 has been implicated in autoinflammatory disorders, such as familial Mediterranean fever (FMF), and hematologic malignancies. Research using CD2BP2 antibodies has also explored its involvement in macrophage differentiation, osteoclastogenesis, and inflammasome activation. These studies highlight its potential as a therapeutic target or biomarker in inflammatory and immune-mediated conditions.
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