Rabbit Polyclonal DHX38 Antibody

The DHX38 antibody is a crucial tool for studying the DEAH-box helicase DHX38. a protein involved in pre-mRNA splicing and genome stability. DHX38. also known as PRP16 homolog, plays a key role in the catalytic activation of the spliceosome during the splicing cycle, facilitating the release of lariat introns and ensuring accurate RNA processing. It is implicated in diverse cellular processes, including cell cycle regulation, DNA repair, and neuronal development. Dysregulation of DHX38 has been linked to diseases such as retinitis pigmentosa and cancer. Researchers utilize DHX38 antibodies in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate its expression, localization, and interactions with spliceosomal components. These antibodies are typically raised in rabbits or mice against specific epitopes of the human DHX38 protein, with validation in knockout models to ensure specificity. Recent studies also explore DHX38's role in alternative splicing events linked to neurodegeneration and its potential as a therapeutic target. The antibody's applications extend to clinical research, particularly in analyzing splicing defects in genetic disorders and cancer biology.