Rabbit Polyclonal HOOK1 Antibody

HOOK1 antibody targets the HOOK1 protein, a member of the Hook family of microtubule-binding proteins conserved across eukaryotes. HOOK1 functions as an adaptor molecule, facilitating intracellular transport by linking organelles to microtubule-based motor proteins. It plays a critical role in endosomal trafficking, lysosomal positioning, and cargo sorting, particularly in specialized cells like neurons and podocytes. Dysregulation of HOOK1 is implicated in cellular transport disorders, neurodegenerative diseases, and cancers. Researchers utilize HOOK1 antibodies in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to study its expression, localization, and interactions in normal and pathological contexts. These antibodies help elucidate HOOK1’s involvement in mechanisms like receptor recycling, organelle motility, and autophagy. Recent studies also explore HOOK1’s potential as a biomarker in renal cell carcinoma and its role in ciliopathies. Commercial HOOK1 antibodies are typically raised in rabbits or mice, validated for specificity against human, mouse, or rat isoforms. Challenges include cross-reactivity with homologous family members (HOOK2/3), necessitating careful validation via knockout controls. Ongoing research aims to clarify HOOK1’s regulatory networks and therapeutic relevance in trafficking-related diseases.