Rabbit Polyclonal FBXL21P Antibody

The FBXL21P antibody is designed to target FBXL21P (F-box and leucine-rich repeat protein 21 pseudogene), a member of the F-box protein family that plays roles in substrate recognition for ubiquitination via the SCF (SKP1-CUL1-F-box) E3 ligase complex. Although classified as a pseudogene due to sequence homology and potential loss of coding capacity, FBXL21P has drawn interest for its possible regulatory functions, including modulating the activity or stability of related functional proteins like FBXL21. Research suggests FBXL21P may influence circadian rhythms, metabolism, or cellular stress responses, though its exact biological role remains unclear. The FBXL21P antibody is typically developed using immunogenic peptides derived from conserved regions of the pseudogene’s predicted protein sequence, if expressed. It is utilized in techniques such as Western blotting, immunohistochemistry, or immunofluorescence to investigate FBXL21P expression patterns, localization, or interactions in various tissues or disease models. Studies involving this antibody aim to clarify whether FBXL21P retains residual function, acts as a non-coding RNA, or impacts neighboring gene regulation. Its application contributes to understanding pseudogene biology and potential roles in diseases like cancer or neurodegenerative disorders. Validation of specificity through knockout controls is critical due to pseudogene homology with functional counterparts.