| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/150-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DIP2; C21orf106 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human DIP2A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DIP2A抗体的3篇参考文献的简要概括(基于公开研究数据整理，非真实文献，仅供参考)：
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1. **文献名称**: *DIP2A regulates synaptic plasticity and cognitive functions through epigenetic modulation*
**作者**: Chen L, et al.
**摘要**: 本研究利用特异性DIP2A抗体，在小鼠模型中揭示了DIP2A蛋白通过调控组蛋白甲基化修饰影响海马区突触可塑性的机制，并发现其缺失导致学习记忆障碍，提示其与神经退行性疾病潜在关联。
2. **文献名称**: *Development and validation of a novel polyclonal antibody against human DIP2A for immunohistochemical analysis*
**作者**: Wang Y, et al.
**摘要**: 文章报道了一种针对人源DIP2A蛋白C端结构域的多克隆抗体的开发，通过Western blot和免疫组化验证其特异性，并应用于脑组织样本检测，证实DIP2A在皮层神经元中高表达。
3. **文献名称**: *DIP2A interacts with DISC1 and modulates Wnt/β-catenin signaling in autism spectrum disorders*
**作者**: Smith J, et al.
**摘要**: 通过免疫共沉淀(使用DIP2A抗体)和基因沉默技术，研究发现DIP2A与精神分裂症相关蛋白DISC1相互作用，并影响Wnt信号通路活性，为自闭症谱系障碍的分子机制提供了新见解。
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**说明**：以上文献为模拟示例，实际引用需以真实发表的论文为准。建议通过PubMed或Google Scholar以“DIP2A antibody”或“DIP2A function”为关键词检索最新研究。
DIP2A (Disco-interacting protein 2 homolog A) is a conserved eukaryotic protein encoded by the *DIP2A* gene, implicated in diverse cellular processes, including neurodevelopment, epigenetic regulation, and mitochondrial function. Structurally, it contains a DNA methyltransferase-associated domain and a disco-interacting region, suggesting roles in protein-protein interactions and enzymatic activity modulation. Studies link DIP2A to neuronal differentiation, synaptic plasticity, and axonal growth, potentially through interactions with transcription factors (e.g., CREB1) or epigenetic modifiers. Dysregulation of DIP2A has been associated with neurodevelopmental disorders (autism, schizophrenia) and cancers, where it may influence cell proliferation, apoptosis, or metabolic pathways via unclear mechanisms.
DIP2A antibodies are essential tools for studying its expression patterns, subcellular localization (nuclear/cytoplasmic), and molecular interactions. Commonly used in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation, these antibodies often target specific epitopes within its N-terminal or C-terminal regions. However, antibody specificity remains a challenge due to DIP2A’s homology with other DIP2 family members (DIP2B/C). Validation via knockout cell lines or siRNA knockdown is recommended. Recent research also explores DIP2A’s role in mitochondrial dynamics and metabolic reprogramming, expanding its relevance in neurodegenerative and oncological contexts.
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