Rabbit Polyclonal EXOSC10 Antibody

The EXOSC10 antibody is a valuable tool for studying the EXOSC10 protein, a critical component of the RNA exosome complex. The exosome is a multi-subunit 3'→5' exoribonuclease complex involved in RNA processing, surveillance, and degradation. EXOSC10 (Exosome Component 10), also known as Rrp6 in yeast, is a nuclear-specific catalytic subunit essential for processing ribosomal RNA (rRNA), small nuclear RNA (snRNA), and aberrant transcripts. It plays a role in quality control by degrading improperly processed or damaged RNAs. Researchers use EXOSC10 antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and interactions. These antibodies are crucial for exploring EXOSC10's involvement in cellular processes, including cell cycle regulation, DNA repair, and stress responses. Dysregulation of EXOSC10 has been linked to diseases such as cancer and neurodegenerative disorders, making its study clinically relevant. Commercially available EXOSC10 antibodies are typically raised in rabbits or mice against specific epitopes, with validation in knockout controls to ensure specificity. Their applications span basic research on RNA metabolism, mechanistic studies of exosome function, and biomarker discovery in pathological conditions.