| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | dJ126A5.1 |
| WB Predicted band size | 63 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human DNAJC11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DNAJC11抗体的模拟参考文献示例(注：以下内容为虚构，仅用于示例格式，建议通过学术数据库查询真实文献)：
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1. **标题**：DNAJC11 regulates mitochondrial membrane dynamics through interaction with MICOS complex
**作者**：Smith A, et al.
**摘要**：本研究利用DNAJC11特异性抗体，通过免疫荧光和免疫印迹技术，揭示了DNAJC11蛋白在线粒体内膜组织(MICOS复合体)中的关键作用，证明其缺失导致线粒体嵴结构异常和细胞能量代谢紊乱。
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2. **标题**：Characterization of DNAJC11 expression in neurodegenerative disease models
**作者**：Johnson B, Lee C.
**摘要**：通过Western blot和免疫组化分析，作者发现DNAJC11在帕金森病模型小鼠脑组织中表达显著上调，提示其可能参与错误折叠蛋白的清除机制，DNAJC11抗体被用于标记神经元中的蛋白定位。
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3. **标题**：DNAJC11 interacts with HSP60 to modulate protein folding in the mitochondrial matrix
**作者**：Wang X, et al.
**摘要**：研究通过免疫共沉淀(Co-IP)和质谱分析，证实DNAJC11与HSP60存在直接相互作用，依赖其抗体验证了二者在应激条件下协同维持线粒体基质内蛋白质稳态的功能。
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4. **标题**：A novel role of DNAJC11 in apoptosis: Evidence from antibody-mediated knockdown experiments
**作者**：Garcia R, et al.
**摘要**：利用DNAJC11抗体进行功能阻断实验，发现抑制DNAJC11会激活线粒体凋亡通路，导致细胞色素c释放和caspase-3活化，表明其在细胞存活调控中的新机制。
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如需真实文献，建议通过PubMed、Google Scholar等平台以“DNAJC11 antibody”或“DNAJC11 function”为关键词检索。
The DNAJC11 antibody targets a protein encoded by the *DNAJC11* gene, a member of the evolutionarily conserved DNAJ/Hsp40 family. DNAJC11 is localized to mitochondria and plays a role in mitochondrial membrane protein import, cristae morphology maintenance, and metabolic regulation. It functions as a cochaperone, interacting with HSP70 family proteins to facilitate protein folding, stability, and intracellular trafficking. Structurally, DNAJC11 contains a J-domain critical for HSP70 binding, along with transmembrane domains anchoring it to the mitochondrial inner membrane.
Research on DNAJC11 has linked it to mitochondrial dynamics, oxidative phosphorylation, and cellular stress responses. Dysregulation of DNAJC11 is implicated in mitochondrial disorders, neurodegenerative diseases, and cancer. For instance, reduced DNAJC11 expression may impair mitochondrial function, contributing to neurodegeneration, while overexpression has been observed in certain cancers, suggesting a role in tumor cell survival.
Antibodies against DNAJC11 are widely used in Western blotting, immunofluorescence, and immunohistochemistry to study its expression patterns, subcellular localization, and interactions. These tools help elucidate its physiological and pathological roles, offering insights into disease mechanisms and potential therapeutic targets. Commercial DNAJC11 antibodies are typically validated for specificity across human, mouse, and rat models, aiding comparative studies in mitochondrial biology and disease.
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