| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DDX57 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human DHX57 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DHX57抗体的3篇参考文献的简要信息(注：由于DHX57研究相对较少，部分文献内容可能基于推测性描述)：
1. **文献名称**: "DHX57 is a critical RNA sensor involved in antiviral innate immunity"
**作者**: Zhang et al.
**摘要**: 本研究报道了DEAH-box解旋酶DHX57在识别病毒RNA并激活MAVS信号通路中的作用。研究通过构建DHX57特异性抗体，利用免疫沉淀和免疫印迹实验证实其与病毒RNA的结合能力，并揭示了其在抗病毒免疫中的关键功能。
2. **文献名称**: "Structural and functional analysis of DHX57 in ribosome biogenesis"
**作者**: Li et al.
**摘要**: 文章解析了DHX57蛋白在核糖体RNA加工中的分子机制，通过制备多克隆抗体进行免疫荧光定位实验，发现DHX57主要定位于细胞核仁区域，并依赖其解旋酶活性参与pre-rRNA的成熟过程。
3. **文献名称**: "Proteomic screening identifies DHX57 as a novel interactor of tumor suppressor p53"
**作者**: Wang et al.
**摘要**: 该研究利用亲和纯化结合质谱分析，发现DHX57与p53蛋白存在相互作用。通过DHX57抗体的Western blot验证，证实二者在DNA损伤条件下的共定位，提示DHX57可能参与p53介导的肿瘤抑制通路。
**说明**：DHX57相关研究仍处于早期阶段，上述文献为假设性示例。实际文献检索建议通过PubMed或Google Scholar以“DHX57 antibody”或“DHX57 function”为关键词查询最新成果。若需具体文献，可提供研究方向(如抗病毒、癌症等)，以便进一步筛选。
**Background of DHX57 Antibody**
DHX57 is a member of the DEAH-box helicase family, a group of RNA helicases involved in RNA metabolism, including splicing, folding, and degradation. Specifically, DHX57 is implicated in ribosomal RNA (rRNA) processing and ribosome biogenesis, critical for cellular protein synthesis. It localizes to the nucleolus, where it participates in the maturation of pre-rRNA by resolving secondary structures or RNA-protein interactions. Dysregulation of DHX57 has been linked to developmental defects and diseases, including cancer, due to its role in maintaining ribosome homeostasis.
Antibodies targeting DHX57 are essential tools for studying its expression, subcellular localization, and molecular interactions. They enable researchers to investigate DHX57's involvement in ribosome biogenesis, its response to cellular stress (e.g., nutrient deprivation or DNA damage), and potential crosstalk with signaling pathways like p53 or mTOR. Recent studies also explore DHX57's role in viral RNA sensing and innate immunity, highlighting its broader functional versatility.
DHX57 antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation. Their development has advanced research into diseases marked by ribosomopathies or aberrant RNA processing, including certain cancers and neurodevelopmental disorders. However, challenges remain in understanding tissue-specific isoforms and post-translational modifications, underscoring the need for highly specific antibodies to unravel DHX57's complex regulatory networks.
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