首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal H4C1 Antibody

  • 中文名: H4C1抗体
  • 别    名: H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4FA; H4-16; H4C11; H4C12; H4C13; H4C14; H4C15; HIST1H4A
货号: IPDX10496
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是3篇关于H4C1抗体的参考文献(示例为模拟生成内容,实际文献需通过数据库验证):

---

1. **文献名称**: "Histone H4 acetylation dynamics determined by stable isotope labeling with amino acids in cell culture and mass spectrometry"

**作者**: Smith A, et al.

**摘要**: 本研究利用H4C1特异性抗体,结合SILAC标记和质谱技术,定量分析了HeLa细胞中组蛋白H4乙酰化修饰的动态变化,揭示了其在细胞周期进程中的调控作用。

---

2. **文献名称**: "Chromatin immunoprecipitation analysis of histone H4K12 acetylation in neuronal differentiation"

**作者**: Chen L, et al.

**摘要**: 通过H4C1抗体(针对H4K12乙酰化位点)进行ChIP-seq,发现该修饰在小鼠神经干细胞分化过程中显著富集于神经元特异性基因启动子区域,提示其参与神经分化表观调控。

---

3. **文献名称**: "Aberrant histone H4 modification in hepatocellular carcinoma revealed by antibody-based profiling"

**作者**: Tanaka K, et al.

**摘要**: 采用多种组蛋白抗体(包括H4C1)对肝癌组织进行免疫组化分析,发现H4K16乙酰化水平显著降低,可能与肝癌患者预后不良相关。

---

注:以上内容为模拟生成,实际文献需通过PubMed或Google Scholar以关键词“H4C1 antibody”“H4 histone modification”等检索。建议结合具体研究场景筛选抗体应用(如ChIP、WB、IF等)相关的论文。

背景信息

The H4C1 antibody specifically targets histone H4. a core component of nucleosomes that package DNA into chromatin. Histone H4. encoded by multiple genes (e.g., H4C1. H4C2), plays a critical role in maintaining chromatin structure and regulating gene expression through post-translational modifications (e.g., acetylation, methylation). As a highly conserved protein, H4 is essential for DNA replication, repair, and epigenetic regulation. The H4C1 antibody is commonly used in epigenetics research to investigate histone modification patterns, chromatin dynamics, and their roles in cellular processes like transcription and genome stability. It is widely applied in techniques such as chromatin immunoprecipitation (ChIP), Western blotting, and immunofluorescence. Commercial H4C1 antibodies are typically raised against synthetic peptides corresponding to conserved regions of human H4 and are validated for specificity across species. Its utility extends to studying diseases linked to chromatin dysregulation, including cancer and developmental disorders. Researchers rely on H4C1 antibodies to explore histone variant functions, nucleosome remodeling, and the interplay between histone modifications and cellular signaling pathways.

客户数据及评论

折叠内容

大包装询价

×