Rabbit Polyclonal KCTD18 Antibody

The KCTD18 antibody is designed to target the potassium channel tetramerization domain-containing protein 18 (KCTD18), a member of the KCTD family implicated in diverse cellular processes. KCTD proteins typically feature a conserved N-terminal BTB/POZ domain, facilitating protein-protein interactions, and a variable C-terminal region. While the specific biological role of KCTD18 remains less characterized compared to other family members (e.g., KCTD5. KCTD12), emerging studies suggest its involvement in modulating ubiquitination pathways, transcriptional regulation, or ion channel activity, potentially through interactions with cullin-3 or other signaling complexes. KCTD18 antibodies are primarily utilized as research tools to investigate the protein’s expression patterns, subcellular localization, and functional mechanisms in physiological and pathological contexts, such as neurodevelopment, cancer, or immune responses. Commercial and custom antibodies are often validated for applications like Western blotting, immunofluorescence, and co-immunoprecipitation. However, limited literature on KCTD18 underscores the need for further exploration of its molecular interactions and disease relevance. These antibodies are critical for elucidating its role in cellular homeostasis, offering potential insights into therapeutic targets for disorders linked to KCTD protein dysregulation.