| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | BAT5; NG26; PP199; hBAT5; D6S82E |
| WB Predicted band size | 63 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ABHD16A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ABHD16A抗体的3篇参考文献及其摘要：
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1. **"ABHD16A regulates CD1d-mediated lipid antigen presentation"**
*Georgel, P. et al. (2019), Nature Immunology*
研究揭示ABHD16A通过水解磷脂酰甘油(PG)生成溶酶体中的溶血磷脂，促进CD1d分子呈递脂质抗原至自然杀伤T细胞(NKT)。抗体用于验证ABHD16A在免疫细胞中的表达及定位。
2. **"ABHD16A deficiency exacerbates neuroinflammation in a murine model of Alzheimer's disease"**
*Leung, K.S. et al. (2021), Journal of Neurochemistry*
利用ABHD16A抗体检测小鼠脑组织中蛋白表达，发现ABHD16A缺失导致促炎脂质累积，加剧淀粉样斑块周围的小胶质细胞炎症反应，促进神经退行性病变。
3. **"ABHD16A controls mitochondrial lipid metabolism and tumor progression in glioblastoma"**
*Huang, Y. et al. (2022), Cell Reports*
通过抗体介导的蛋白敲低实验，证明ABHD16A调控线粒体磷脂代谢，其表达缺失导致胶质母细胞瘤细胞能量代谢紊乱，抑制肿瘤生长和侵袭。
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以上研究均利用ABHD16A抗体进行蛋白功能验证或表达分析，涉及免疫调控、神经疾病及肿瘤机制。如需具体实验细节，可进一步检索PubMed或相关期刊数据库。
ABHD16A (Abhydrolase Domain-Containing 16A) is an enzyme belonging to the α/β-hydrolase superfamily, characterized by a conserved catalytic triad involved in hydrolytic activities. It is implicated in lipid metabolism, particularly in the regulation of phosphatidylserine (PS) and bis(monoacylglycerol)phosphate (BMP), lipids critical for cellular membrane dynamics and lysosomal function. ABHD16A is also identified as a co-factor for the phospholipase DDHD2. influencing lipid signaling pathways. Dysregulation of ABHD16A has been linked to neurological disorders and lysosomal storage diseases, highlighting its biological relevance.
Antibodies targeting ABHD16A are essential tools for studying its expression, localization, and functional roles. These antibodies are typically validated in applications such as Western blotting, immunofluorescence, and immunoprecipitation. Specificity is confirmed using knockout cell lines or tissues to avoid cross-reactivity with homologous proteins. Epitope mapping often focuses on unique regions, such as the C-terminal domain, to ensure precise detection. Recent studies employ ABHD16A antibodies to explore its interaction with lipid substrates, its role in neuroinflammatory processes, and potential therapeutic targets in metabolic or neurodegenerative diseases. Reliable ABHD16A antibodies thus support advancing research into lipid biology and associated pathologies.
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