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Rabbit Polyclonal PALMD Antibody

  • 中文名: PALMD抗体
  • 别    名: PALML; C1orf11
货号: IPDX10565
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesPALML; C1orf11
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human PALMD
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3条与PALMD抗体相关的假设性文献示例(基于公开研究主题推测,实际文献请通过数据库核实):

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1. **文献名称**: *Palmdelphin (PALMD) as a novel biomarker in atherosclerotic plaque instability*

**作者**: Smith A, et al.

**摘要**: 研究通过免疫组化和Western blot分析发现,PALMD蛋白在人类动脉粥样硬化斑块中的表达显著上调,并与平滑肌细胞表型转化相关。使用特异性PALMD抗体证实其可能通过调控炎症通路参与斑块稳定性。

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2. **文献名称**: *PALMD promotes cancer cell migration via RhoA signaling in prostate adenocarcinoma*

**作者**: Chen L, et al.

**摘要**: 研究利用PALMD抗体进行免疫荧光染色,发现PALMD在前列腺癌组织中高表达,并通过激活RhoA信号通路促进肿瘤细胞迁移。基因敲低实验进一步验证了其功能。

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3. **文献名称**: *Developmental expression and functional analysis of Palmdelphin in murine neural tissues*

**作者**: Gonzalez R, et al.

**摘要**: 通过PALMD抗体的免疫组织化学分析,揭示了PALMD在小鼠胚胎神经发育中的时空特异性表达模式,体外实验表明其缺失会导致神经元突触形成异常。

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**注意**:以上为模拟示例,实际文献需通过PubMed、Google Scholar等平台以关键词“PALMD antibody”或“Palmdelphin”检索。若需具体文献,建议补充研究背景(如疾病领域/实验技术)。

背景信息

The PALMD (Palmdelphin) antibody targets a protein belonging to the synaptic vesicle-associated membrane protein family, which shares homology with synaptotagmins. PALMD encodes a cytosolic protein predominantly expressed in cardiac and neuronal tissues, characterized by two C2 domains that mediate calcium-dependent membrane interactions. It plays a role in regulating intracellular trafficking, exocytosis, and calcium signaling, potentially influencing synaptic transmission and vesicle dynamics. Studies suggest PALMD interacts with proteins involved in membrane fusion, such as syntaxins, and may modulate pathways linked to cardiovascular function and neurodegeneration. Dysregulation of PALMD has been implicated in pathologies like dilated cardiomyopathy and Alzheimer’s disease. Antibodies against PALMD are widely used in research to investigate its expression, localization, and mechanistic roles via techniques like Western blot, immunohistochemistry, and immunofluorescence. Recent interest in PALMD also extends to cancer biology, where its aberrant expression may correlate with tumor progression. These tools help unravel its physiological and pathological contributions, aiding therapeutic target discovery.

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