| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IPOA7 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human KPNA6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与KPNA6抗体相关的文献概览，基于领域研究整理：
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1. **文献名称**: *KPNA6 regulates histone H3 phosphorylation and promotes neurogenesis*
**作者**: Smith A, et al.
**摘要**: 本研究利用KPNA6特异性抗体进行染色质免疫沉淀(ChIP)实验，发现KPNA6通过与组蛋白H3磷酸化通路相关蛋白相互作用，调控神经干细胞的增殖与分化。
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2. **文献名称**: *Nuclear import of HIV-1 integrase is mediated by KPNA6: Insights from siRNA and antibody-based inhibition*
**作者**: Lee JH, et al.
**摘要**: 通过KPNA6抗体阻断实验和免疫荧光成像，揭示了HIV-1整合酶依赖KPNA6完成核转运的分子机制，为抗病毒药物开发提供了新靶点。
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3. **文献名称**: *Altered expression of KPNA6 in hepatocellular carcinoma correlates with patient prognosis*
**作者**: Wang Y, et al.
**摘要**: 采用KPNA6抗体对肝癌组织进行免疫组化分析，发现KPNA6表达水平与肿瘤转移和患者生存率显著相关，提示其作为肝癌预后标志物的潜力。
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*注：以上文献为示例模板，实际引用时需通过PubMed/Google Scholar检索真实文献(可尝试关键词"KPNA6 antibody" + "nuclear import"/"cancer"/"viral infection")。建议优先选择近5年且抗体验证信息明确(如货号、应用场景)的研究。*
The KPNA6 antibody is a crucial tool for studying the function and expression of Karyopherin alpha 6 (KPNA6), a member of the importin-α family involved in nucleocytoplasmic transport. KPNA6. encoded by the *KPNA6* gene, facilitates protein import into the nucleus by binding to cargo proteins containing classical nuclear localization signals (NLS) and interacting with importin-β1 (KPNB1) to mediate translocation through nuclear pores. This protein is part of a larger family with seven isoforms (KPNA1–7) in humans, each exhibiting tissue-specific expression and substrate preferences. KPNA6 is particularly noted for its role in development, immune regulation, and disease processes, including viral infections and cancer.
Antibodies targeting KPNA6 are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect its expression, subcellular localization, and interactions. These antibodies aid in elucidating KPNA6's involvement in cellular pathways, such as its potential dysregulation in tumors or its interaction with viral proteins that hijack nuclear import machinery. Validation of KPNA6 antibodies typically includes specificity checks using knockout cell lines or siRNA knockdown to ensure minimal cross-reactivity with other KPNA isoforms. High-quality antibodies are essential for reliable research, as aberrant KPNA6 expression has been linked to cancer progression, making it a biomarker candidate. Researchers prioritize antibodies with confirmed reactivity across human and model organisms to support translational studies.
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