| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CGA |
| Entrez GeneID | 1113 |
| clone | 1A6B6 |
| WB Predicted band size | 50.7kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CHGA (AA: 87-252 ) expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是模拟生成的关于ADM2抗体的参考文献示例(非真实文献，仅供格式参考)：
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1. **文献名称**: *ADM2 Antibody Development for Cardiovascular Disease Research*
**作者**: Smith A, et al.
**摘要**: 研究团队开发了一种高特异性ADM2多克隆抗体，用于检测ADM2在动脉粥样硬化斑块中的表达，证实ADM2通过调控血管平滑肌细胞增殖参与疾病进展。
2. **文献名称**: *Role of ADM2 in Tumor Angiogenesis: Insights from Neutralizing Antibody Studies*
**作者**: Chen L, et al.
**摘要**: 通过ADM2中和抗体的体内实验，发现ADM2通过激活PI3K/AKT通路促进肿瘤血管生成，抗体干预显著抑制小鼠模型中结肠癌的生长。
3. **文献名称**: *ADM2-Specific Monoclonal Antibody as a Potential Therapeutic Agent for Hypertension*
**作者**: Tanaka K, et al.
**摘要**: 报道了一种新型抗ADM2单克隆抗体的开发，其可降低ADM2介导的血管通透性异常，并在高血压大鼠模型中显示出血压调控潜力。
4. **文献名称**: *ADM2 Expression in Inflammatory Bowel Disease: Validation by Immunohistochemistry*
**作者**: Müller R, et al.
**摘要**: 利用ADM2特异性抗体进行组织染色，发现ADM2在克罗恩病患者肠道组织中的表达显著上调，提示其与炎症细胞因子的相互作用。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词(如"ADM2 antibody"、"Adrenomedullin 2 antibody")，并筛选应用类或机制研究类论文。
ADM2 (Adrenomedullin 2), also known as intermedin, is a peptide hormone belonging to the calcitonin gene-related peptide (CGRP) family. It shares structural and functional similarities with adrenomedullin (ADM), both playing roles in cardiovascular regulation, fluid homeostasis, and cellular proliferation. ADM2 binds to receptors formed by calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs), activating signaling pathways like cAMP and MAPK. It is widely expressed in tissues, including the heart, kidneys, and vascular endothelium, and is implicated in vasodilation, anti-inflammatory responses, and tissue protection under hypoxic or ischemic conditions.
ADM2 antibodies are essential tools for detecting and quantifying this peptide in research and diagnostics. They enable studies on ADM2’s involvement in diseases such as hypertension, heart failure, chronic kidney disease, and cancer. Commercially available antibodies (polyclonal or monoclonal) are validated for techniques like ELISA, immunohistochemistry, and Western blot. Their specificity helps clarify ADM2’s pathophysiological roles, including its dual effects in promoting angiogenesis in tumors while protecting against vascular injury. Challenges remain in distinguishing cross-reactivity with ADM due to sequence homology, emphasizing the need for rigorously validated antibodies. Ongoing research explores ADM2 as a potential therapeutic target or biomarker, driving demand for reliable detection tools.
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