| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | K16; CK16; K1CP; NEPPK; FNEPPK; KRT16A |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human KRT16 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是模拟生成的3篇关于KRT16抗体的参考文献示例(实际文献需通过学术数据库验证)：
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1. **文献名称**：*KRT16 Expression in Psoriatic Epidermis: A Marker of Hyperproliferation*
**作者**：Smith J, et al.
**摘要**：本研究利用特异性KRT16抗体进行免疫组化分析，发现银屑病患者表皮中KRT16显著上调，与角质形成细胞异常增殖相关，提示其作为银屑病病理生物标志物的潜力。
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2. **文献名称**：*Development of a Monoclonal Antibody Against Human KRT16 for Cancer Diagnostics*
**作者**：Lee H, et al.
**摘要**：报道了一种新型抗人KRT16单克隆抗体的开发与验证。该抗体在胰腺癌和口腔鳞状细胞癌组织中表现出高特异性，可用于区分恶性与正常上皮组织。
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3. **文献名称**：*KRT16 Antibody Reveals Dynamic Expression During Wound Healing*
**作者**：Garcia R, et al.
**摘要**：通过KRT16抗体追踪小鼠皮肤伤口愈合过程，发现KRT16在修复早期阶段短暂高表达，可能与上皮迁移和屏障功能重建相关。
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**注**：以上内容为示例，实际文献请通过 **PubMed/Google Scholar** 检索关键词如 "KRT16 antibody" 或 "anti-KRT16 application" 获取。部分真实研究可能涉及：
- KRT16在炎症性皮肤病、癌症及伤口修复中的功能
- 抗体在诊断或机制研究中的技术应用(如Western blot、IHC)
Keratin 16 (KRT16) is a type I intermediate filament protein encoded by the *KRT16* gene, primarily expressed in stratified epithelia, including the skin, nails, and mucosal tissues. It plays a critical role in maintaining epithelial integrity, cell proliferation, and stress response. KRT16 is often co-expressed with KRT6 in hyperproliferative or damaged epithelia, forming a heterodimer that stabilizes the cytoskeleton during tissue repair or inflammation. Dysregulation of KRT16 is linked to pathological conditions such as psoriasis, eczema, and pachyonychia congenita (a genetic disorder causing thickened nails and palmoplantar keratoderma). It is also implicated in tumorigenesis, particularly in squamous cell carcinomas and certain adenocarcinomas.
KRT16 antibodies are essential tools for detecting this protein in research and diagnostics. They are widely used in immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting to study its expression patterns in normal vs. diseased tissues. Commercially available antibodies target specific epitopes, enabling precise localization and quantification. Recent studies explore KRT16's role in immune modulation, wound healing, and cancer metastasis, highlighting its potential as a biomarker or therapeutic target. Validation of KRT16 antibodies ensures specificity and reproducibility, crucial for advancing understanding of epithelial biology and associated disorders.
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