| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | FBLN, FIBL1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human FBLN1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于FBLN1抗体的3篇参考文献的简要概括：
1. **文献名称**: "Fibulin-1 suppression of tumorigenicity in ovarian cancer cells"
**作者**: Gallagher WM et al.
**摘要**: 该研究利用FBLN1特异性抗体检测卵巢癌细胞中Fibulin-1的表达，发现其表达下调与肿瘤侵袭性增强相关，提示FBLN1可能通过抑制基质金属蛋白酶(MMPs)发挥抑癌作用。
2. **文献名称**: "Extracellular matrix protein FBLN1 regulates endothelial barrier function via integrin signaling"
**作者**: Chen Y et al.
**摘要**: 通过FBLN1抗体进行免疫荧光和Western blot分析，研究发现Fibulin-1通过与内皮细胞整合素互作，调控血管通透性及炎症反应中的屏障功能。
3. **文献名称**: "FBLN1 as a biomarker for early detection of liver fibrosis"
**作者**: Li H et al.
**摘要**: 该研究使用FBLN1抗体对肝组织样本进行免疫组化分析，发现Fibulin-1在纤维化肝脏中显著上调，可作为肝纤维化早期诊断的潜在血清标志物。
注：以上文献信息为示例性内容，实际文献需通过PubMed/Google Scholar等平台检索确认。
The Fibulin-1 (FBLN1) antibody is a tool used to detect and study the Fibulin-1 protein, a member of the extracellular matrix (ECM) glycoprotein family. FBLN1 plays critical roles in cell adhesion, migration, and tissue organization by interacting with ECM components like fibronectin, laminin, and proteoglycans. It exists in multiple isoforms (A-D) generated by alternative splicing, contributing to its functional diversity in developmental processes, wound healing, and disease pathogenesis. Dysregulation of FBLN1 has been implicated in cancer progression, cardiovascular disorders, and connective tissue diseases, making it a focus of biomedical research.
FBLN1 antibodies, typically polyclonal or monoclonal, are designed to target specific epitopes or isoforms of the protein. They are widely utilized in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to analyze FBLN1 expression, localization, and post-translational modifications in tissues or cell lines. These antibodies help elucidate FBLN1’s dual roles in tumor suppression (e.g., inhibiting angiogenesis) and tumor promotion (e.g., facilitating metastasis), depending on cellular context. Commercial FBLN1 antibodies are often validated for specificity and sensitivity across human, mouse, or rat samples. Research using these antibodies has advanced understanding of ECM remodeling mechanisms and their implications in fibrosis, atherosclerosis, and cancer microenvironment regulation.
×
