关键信息
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基因名
TGFBI
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简介
TGFBI Protein, a multifaceted regulator, plays a crucial role in cell adhesion, influencing diverse cellular processes. Its binding affinity for various collagens, such as type I, II, and IV, underscores its significance in mediating cellular responses and adhesion-related events. The protein's involvement in extracellular matrix interactions highlights its potential impact on cellular adhesion to different collagen types. TGFBI Protein, Human (HEK293, His, solution) is the recombinant human-derived TGFBI protein, expressed by HEK293 , with C-10*His labeled tag.
- 应用
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别名
Transforming growth factor-beta-induced protein ig-h3; Beta ig-h3; RGD-CAP; BIGH3
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种属
Human
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表达系统
HEK293
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标签
C-10*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15582
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表达区间
G24-H683
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氨基酸序列
GPAKSPYQLVLQHSRLRGRQHGPNVCAVQKVIGTNRKYFTNCKQWYQRKICGKSTVISYECCPGYEKVPGEKGCPAALPLSNLYETLGVVGSTTTQLYTDRTEKLRPEMEGPGSFTIFAPSNEAWASLPAEVLDSLVSNVNIELLNALRYHMVGRRVLTDELKHGMTLTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVISTITNNIQQIIEIEDTFETLRAAVAASGLNTMLEGNGQYTLLAPTNEAFEKIPSETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGLSVETLEGTTLEVGCSGDMLTINGKAIISNKDILATNGVIHYIDELLIPDSAKTLFELAAESDVSTAIDLFRQAGLGNHLSGSERLTLLAPLNSVFKDGTPPIDAHTRNLLRNHIIKDQLASKYLYHGQTLETLGGKKLRVFVYRNSLCIENSCIAAHDKRGRYGTLFTMDRVLTPPMGTVMDVLKGDNRFSMLVAAIQSAGLTETLNREGVYTVFAPTNEAFRALPPRERSRLLGDAKELANILKYHIGDEILVSGGIGALVRLKSLQGDKLEVSLKNNVVSVNKEPVAEPDIMATNGVVHVITNVLQPPANRPQERGDELADSALEIFKQASAFSRASQRSVRLAPVYQKLLERMKH
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蛋白长度
Full Length of Mature Protein
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分子量
65 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
TGFBI (Transforming Growth Factor Beta Inducible) protein, also known as TGFBIp or beta ig-h3, is a secreted extracellular matrix protein that plays a critical role in cellular adhesion, migration, and tissue repair processes. It is notably induced by TGF-β, which links it to various physiological and pathological conditions, including fibrosis, cancer, and wound healing. Research into TGFBI has gained traction due to its involvement in diverse biological functions and its potential as a therapeutic target. Recent studies reveal its significance in ocular diseases, particularly corneal dystrophies, where mutations in the TGFBI gene can lead to abnormal protein accumulation and impaired vision. The recombinant TGFBI protein is being explored in various applications, including cell culture studies, functional assays, and therapeutic interventions. By generating TGFBI as a recombinant protein, researchers aim to better understand its structural characteristics and biological activities, ultimately contributing to the development of novel treatment strategies for TGFBI-related disorders. Understanding the molecular mechanisms underpinning TGFBI functions could reveal new insights into tissue engineering, regenerative medicine, and the design of biomaterials that mimic its properties for enhanced healing and repair.
