| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/5-1/20 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | AXSF, AXLLG |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human GAS6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GAS6抗体的3篇参考文献示例(内容为模拟虚构，仅供参考)：
1. **"GAS6/AXL Signaling Regulates Tumor Cell Survival and Metastasis"**
- 作者：Stenhoff J, et al.
- 摘要：研究通过特异性抗GAS6抗体阻断GAS6与AXL受体结合，证明其在抑制肿瘤细胞迁移和增强化疗敏感性中的作用。
2. **"Role of GAS6 in Liver Fibrosis: Detection via Immunohistochemical Analysis"**
- 作者：Nagai T, et al.
- 摘要：利用抗GAS6抗体进行肝组织染色，发现GAS6水平与纤维化程度正相关，提示其作为潜在生物标志物的价值。
3. **"Neutralizing Anti-GAS6 Antibody Attenuates Inflammation in Murine Sepsis Models"**
- 作者：Avramidis A, et al.
- 摘要：开发中和型GAS6抗体，证实其通过抑制TLR4通路减轻全身炎症反应，为脓毒症治疗提供新策略。
注：以上文献信息为示例，实际引用需根据具体研究检索PubMed或Google Scholar获取。
Growth arrest-specific 6 (GAS6) is a vitamin K-dependent protein that acts as a key ligand for the TAM receptor tyrosine kinase family (Tyro3. Axl, and Mer). It plays critical roles in regulating cellular processes such as survival, proliferation, migration, and immune modulation by activating downstream signaling pathways, including PI3K/AKT and MAPK. GAS6 is implicated in various physiological and pathological conditions, including inflammation, cancer progression, thrombosis, and tissue repair.
Antibodies targeting GAS6 are essential tools for studying its expression, function, and interaction with TAM receptors. They are widely used in research applications like Western blotting, immunohistochemistry, ELISA, and flow cytometry to quantify GAS6 levels in tissues or biological fluids. In therapeutic contexts, GAS6-neutralizing antibodies are being explored to inhibit oncogenic signaling, particularly in cancers with Axl receptor overexpression, where GAS6/AXL signaling promotes metastasis, drug resistance, and immune evasion. Additionally, these antibodies help elucidate GAS6's role in diseases like chronic kidney injury, fibrosis, and autoimmune disorders.
The development of high-specificity GAS6 antibodies has advanced mechanistic studies and preclinical evaluations, highlighting their potential as diagnostic biomarkers or targeted therapies in diseases driven by dysregulated TAM signaling.
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