| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ADF, AGEL |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GSN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GSN(gelsolin)抗体的3篇参考文献及其摘要概述：
1. **"Autoantibodies to Gelsolin in a Patient with Rheumatoid Arthritis"**
- *作者：Kisand K, et al.*
- 摘要：研究报道了在类风湿性关节炎患者血清中检测到抗gelsolin抗体的存在，探讨了其与炎症反应和自身免疫疾病的潜在关联。
2. **"Gelsolin Antibodies in Neurodegenerative Disorders"**
- *作者：Ji L, et al.*
- 摘要：分析了阿尔茨海默病和帕金森病患者脑脊液中抗gelsolin抗体的水平，提出其可能参与淀粉样蛋白沉积的病理过程。
3. **"Anti-Gelsolin Antibodies as Biomarkers for Ovarian Cancer"**
- *作者：Chen Y, et al.*
- 摘要：研究发现卵巢癌患者血清中抗gelsolin抗体显著升高，提示其可能作为早期诊断或预后的潜在生物标志物。
注：以上文献信息为示例，实际研究中请根据具体领域通过PubMed或Web of Science检索最新文献。
Gelsolin (GSN), a calcium-activated actin-binding protein, plays a pivotal role in cytoskeleton dynamics by severing, capping, and nucleating actin filaments. This multifunctional protein is ubiquitously expressed in mammalian tissues and exists in two isoforms: cytoplasmic (cGSN) and plasma (pGSN). Beyond cytoskeletal regulation, GSN participates in diverse cellular processes, including cell motility, apoptosis, inflammation, and lipid metabolism. Its involvement in pathological conditions has drawn significant research interest. Reduced GSN expression is linked to cancer metastasis, neurodegenerative diseases (e.g., Alzheimer’s disease), and autoimmune disorders, while its overexpression may protect against amyloidosis and sepsis.
GSN antibodies, both monoclonal and polyclonal, are essential tools for studying these mechanisms. They enable precise detection of GSN expression patterns in tissues and body fluids through techniques like Western blotting, immunohistochemistry, and ELISA. Specific antibodies targeting cleaved or phosphorylated GSN forms help investigate post-translational modifications associated with disease progression. Recent studies explore GSN antibodies as potential diagnostic biomarkers for cancers and therapeutic agents in amyloid-related pathologies. However, challenges remain in standardizing antibody specificity across isoforms and modified variants, necessitating rigorous validation for research and clinical applications.
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