| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human ITGA7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ITGA7抗体的3篇参考文献及其简要摘要：
1. **文献名称**: *Integrin α7 Antibody Characterization and Expression in Muscle Development and Disease*
**作者**: Mayer U, et al.
**摘要**: 本研究利用特异性ITGA7抗体分析了整合素α7在小鼠骨骼肌发育和肌营养不良模型中的表达模式。发现ITGA7在肌纤维基底膜中高表达，其表达缺失与肌肉再生功能障碍相关，提示其在维持肌肉结构中的关键作用。
2. **文献名称**: *Targeting Integrin α7 in Cancer Metastasis: A Monoclonal Antibody Approach*
**作者**: Zhang Y, et al.
**摘要**: 通过开发高亲和力的ITGA7单克隆抗体，研究揭示了ITGA7在肿瘤细胞侵袭中的调控作用。抗体阻断实验显示，抑制ITGA7可显著降低黑色素瘤细胞的迁移能力，表明其作为潜在治疗靶点的价值。
3. **文献名称**: *ITGA7 as a Novel Biomarker in Cardiac Fibrosis: Immunohistochemical Analysis*
**作者**: Li H, et al.
**摘要**: 使用ITGA7抗体进行心脏组织免疫组化分析，发现其在心肌纤维化区域显著上调。研究提示ITGA7可能通过调控成纤维细胞-肌成纤维细胞转化参与纤维化进程，为心血管疾病诊断提供了新标志物。
注：以上文献信息为示例性质，实际文献需通过PubMed或Web of Science等平台以关键词“ITGA7 antibody”或“integrin alpha7”检索获取近年研究。
The ITGA7 antibody targets the integrin alpha-7 subunit (ITGA7), a transmembrane receptor critical for cell-extracellular matrix (ECM) interactions. ITGA7 primarily pairs with the beta-1 subunit (ITGB1) to form a laminin-binding integrin complex, predominantly expressed in skeletal and cardiac muscle. This complex facilitates cell adhesion, signaling, and structural stability by anchoring myocytes to laminin-α2 in the basement membrane. Dysregulation of ITGA7 is linked to muscular dystrophies and myopathies, as its absence disrupts muscle integrity, leading to progressive weakness.
ITGA7 antibodies are essential tools in research for detecting protein expression, localization, and function. They are widely used in Western blotting, immunohistochemistry, and flow cytometry to study muscle development, regeneration, and disease mechanisms. In diagnostic contexts, these antibodies help identify ITGA7 deficiencies in patient biopsies, aiding in the subclassification of congenital muscular dystrophies. Recent studies also explore ITGA7's role in cancer metastasis, as altered integrin expression may influence tumor cell invasion.
Available as monoclonal or polyclonal variants, ITGA7 antibodies vary in specificity and applications. Researchers prioritize validation using knockout controls to ensure accuracy. Understanding ITGA7 dynamics continues to inform therapeutic strategies, including gene therapy and ECM-targeted interventions for neuromuscular disorders.
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