| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SMRT; TRAC; CTG26; SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; SMRTE-tau |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human NCOR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于NCOR2抗体的代表性文献(信息基于公开研究整理，非实时数据库检索结果)：
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1. **文献名称**：*NCoR2/SMRT-mediated epigenetic silencing promotes prostate cancer progression*
**作者**：Liao G. et al.
**摘要**：研究利用NCOR2抗体通过染色质免疫沉淀(ChIP)和Western blot技术，揭示NCOR2/SMRT复合物通过抑制雄激素受体(AR)靶基因的表观遗传调控，促进前列腺癌转移的分子机制。
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2. **文献名称**：*Corepressor diversification by alternative mRNA splicing is associated with cell fate specification*
**作者**：Goodson M.L. et al.
**摘要**：通过免疫组化(IHC)和免疫沉淀(IP)结合NCOR2抗体，发现NCOR2的不同剪接变体在胚胎发育中具有组织特异性表达，并调控干细胞分化为脂肪或骨骼细胞的关键通路。
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3. **文献名称**：*Thyroid hormone receptor sumoylation regulates ligand sensitivity and transcriptional output*
**作者**：Rosen M.D. et al.
**摘要**：研究使用NCOR2抗体进行共聚焦显微成像和ChIP-seq，证明NCOR2与甲状腺激素受体(TR)的SUMO化修饰动态结合，影响激素信号通路的敏感性和靶基因表达水平。
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**备注**：以上为示例性内容，实际文献需通过PubMed或Google Scholar以“NCOR2 antibody”或“NCoR2/SMRT”为关键词检索获取最新数据。建议结合研究场景(如癌症、神经科学等)进一步筛选针对性文献。
The nuclear receptor corepressor 2 (NCOR2), also known as SMRT (silencing mediator for retinoid and thyroid hormone receptors), is a transcriptional coregulator involved in gene silencing. It functions by forming complexes with nuclear receptors (e.g., thyroid hormone, estrogen, or retinoic acid receptors) and chromatin-modifying enzymes like histone deacetylases (HDACs), thereby repressing target gene transcription. NCOR2 plays critical roles in development, metabolism, and cellular differentiation, and its dysregulation has been implicated in cancers, metabolic disorders, and neurodegenerative diseases.
Antibodies targeting NCOR2 are essential tools for studying its expression, localization, and interactions in various biological contexts. They are widely used in techniques such as Western blotting, immunoprecipitation, chromatin immunoprecipitation (ChIP), and immunofluorescence to investigate NCOR2's regulatory mechanisms. These antibodies help identify NCOR2's involvement in pathways like hormone signaling, inflammation, and oncogenesis. For instance, altered NCOR2 expression or mutations have been linked to therapy resistance in breast/prostate cancers and defects in lipid metabolism. Validated NCOR2 antibodies are critical for ensuring specificity in detecting its isoforms (~120-150 kDa) and distinguishing it from related corepressors like NCOR1. Their applications extend to both basic research and clinical studies exploring transcriptional repression dynamics.
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