Rabbit Polyclonal SLC1A7 Antibody

The solute carrier family 1 member 7 (SLC1A7), also known as excitatory amino acid transporter 5 (EAAT5), is a glutamate transporter predominantly expressed in the retina and brain. It plays a critical role in regulating extracellular glutamate levels by mediating its uptake into glial cells and neurons, thereby preventing excitotoxicity and maintaining synaptic signaling precision. SLC1A7 antibodies are immunological tools designed to detect and study this protein's expression, localization, and function in biological samples. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate SLC1A7's involvement in retinal signaling, neurodegenerative disorders, and glutamate homeostasis. Research has linked SLC1A7 dysfunction to visual impairments and neurological conditions, making its study relevant for understanding diseases like glaucoma or amyotrophic lateral sclerosis (ALS). However, antibody specificity remains a challenge due to structural similarities among EAAT family members. Validated SLC1A7 antibodies enable researchers to explore its tissue-specific roles, interaction partners, and potential as a therapeutic target. Current studies focus on clarifying its transport mechanisms, modulation by post-translational modifications, and contribution to retinal phototransduction pathways.