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Rabbit Polyclonal CELSR2 Antibody

  • 中文名: CELSR2抗体
  • 别    名: EGFL2; MEGF3; CDHF10; Flamingo1
货号: IPDX11413
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/10000 Human,Mouse,Rat

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参考文献

以下是关于CELSR2抗体的3篇文献示例(信息可能需进一步验证,建议通过学术数据库核对):

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1. **文献名称**: *"CELSR2 regulates mitochondrial apoptosis in neural crest cells during craniofacial development"*

**作者**: Smith A, et al.

**摘要**: 本研究利用CELSR2特异性抗体,通过免疫荧光和Western blot技术,揭示了CELSR2在小鼠颅面神经嵴细胞线粒体凋亡通路中的调控作用,并发现其缺失导致先天性颅面畸形。

2. **文献名称**: *"Prognostic significance of CELSR2 expression in glioblastoma multiforme"*

**作者**: Chen L, et al.

**摘要**: 通过免疫组化分析CELSR2抗体标记的肿瘤样本,发现CELSR2高表达与胶质母细胞瘤患者生存期缩短相关,提示其作为潜在预后标志物的价值。

3. **文献名称**: *"A novel CELSR2 mutation linked to hereditary spastic paraplegia disrupts planar cell polarity signaling"*

**作者**: Wang Y, et al.

**摘要**: 研究通过抗体验证发现,CELSR2基因突变导致患者细胞中极性蛋白异常定位,阐明了CELSR2在平面细胞极性(PCP)信号传导中的关键功能缺陷。

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**注意**:上述文献信息为示例性质,具体内容需通过PubMed、Web of Science等数据库检索确认。建议结合实际研究需求补充最新文献。

背景信息

The CELSR2 (Cadherin EGF LAG Seven-Pass G-Type Receptor 2) antibody is a tool used to detect and study the CELSR2 protein, a member of the non-clustered protocadherin family within the cadherin superfamily. CELSR2 is a key component of the planar cell polarity (PCP) pathway, which regulates tissue organization and cell orientation during embryonic development. It plays critical roles in neural tube closure, cardiovascular development, and tissue morphogenesis by mediating cell-cell adhesion and signaling. Dysregulation of CELSR2 has been implicated in congenital disorders, cancers, and neurodevelopmental conditions. The antibody specifically targets epitopes of CELSR2. enabling researchers to investigate its expression, localization, and interactions in various biological contexts. It is widely used in techniques like Western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. Validation of CELSR2 antibodies often includes knockout controls or siRNA-based silencing to confirm specificity. Commercial sources offer monoclonal and polyclonal variants, with applications spanning developmental biology, oncology, and neuroscience research. Proper validation ensures reliability in both research and diagnostic settings, aiding mechanistic studies of CELSR2-associated pathways and pathologies.

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