| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | ADRA1; ALPHA1BAR |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human ADRA1B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及ADRA1B抗体的代表性文献示例(注：文献信息为模拟生成，仅供参考)：
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1. **文献名称**: "Differential expression of α1-adrenergic receptor subtypes in the prefrontal cortex of schizophrenia patients"
**作者**: Smith J, et al.
**摘要**: 通过免疫组化技术比较精神分裂症患者与健康对照组前额叶皮质中ADRA1B蛋白表达水平，发现患者ADRA1B表达显著升高，提示其可能参与精神疾病病理过程。
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2. **文献名称**: "ADRA1B antibody validation in cardiac hypertrophy models using knockout mice"
**作者**: Lee H, et al.
**摘要**: 利用ADRA1B基因敲除小鼠验证商业化抗体的特异性，通过Western blot和免疫荧光证明该抗体能特异性识别心脏肥大模型中ADRA1B蛋白的上调。
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3. **文献名称**: "Role of ADRA1B in prostate cancer progression: A immunohistochemical study"
**作者**: García-Rojas P, et al.
**摘要**: 在200例前列腺癌组织样本中，使用ADRA1B抗体进行免疫组化分析，发现高表达ADRA1B与肿瘤侵袭性和患者不良预后显著相关。
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注：实际文献需通过PubMed/Google Scholar等平台检索确认。建议使用关键词“ADRA1B antibody”、“alpha-1B adrenergic receptor immunohistochemistry”查找最新研究。
The ADRA1B antibody is designed to target the alpha-1B adrenergic receptor (ADRA1B), a member of the G protein-coupled receptor (GPCR) family. This receptor is primarily activated by catecholamines like norepinephrine and epinephrine, playing a critical role in mediating sympathetic nervous system responses, including vasoconstriction, smooth muscle contraction, and modulation of neurotransmitter release. ADRA1B is encoded by the ADRA1B gene and is predominantly expressed in the cardiovascular system, brain, and peripheral tissues.
Antibodies against ADRA1B are widely used in research to study receptor localization, expression levels, and signaling mechanisms in both normal physiology and disease contexts. For example, ADRA1B has been implicated in hypertension, benign prostatic hyperplasia, and neurological disorders due to its role in regulating vascular tone and neural activity. Researchers employ techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to validate ADRA1B presence in tissue samples or cell lines.
Commercial ADRA1B antibodies are typically raised in hosts like rabbits or mice, using immunogenic peptides derived from specific regions of the receptor (e.g., extracellular or intracellular domains). Validation includes testing for specificity via knockout controls or siRNA-mediated silencing. Reliable antibodies are essential for elucidating ADRA1B's functional roles and its potential as a therapeutic target in adrenergic pathway-related diseases.
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