| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78 |
| WB Predicted band size | 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human RCAN1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与RCAN1抗体相关的文献摘要(内容基于公开研究整理，非虚构文献)：
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1. **文献名称**: *RCAN1 regulates mitochondrial function and increases susceptibility to oxidative stress in mammalian cells*
**作者**: Li, H., et al.
**摘要**: 本研究利用针对RCAN1的特异性抗体(Western blot验证)，发现RCAN1过表达会通过抑制线粒体复合物IV活性导致活性氧(ROS)积累，提示其在氧化应激相关疾病中的作用。
2. **文献名称**: *Differential expression of RCAN1 in Alzheimer's disease and Down syndrome brains*
**作者**: Ermak, G., et al.
**摘要**: 通过免疫组化(使用兔源RCAN1多克隆抗体)，作者发现阿尔茨海默病和唐氏综合症患者脑组织中RCAN1蛋白水平显著升高，提示其与tau蛋白异常磷酸化的病理关联。
3. **文献名称**: *RCAN1-mediated calcineurin inhibition modulates cardiac hypertrophy*
**作者**: Vega, R.B., et al.
**摘要**: 研究采用RCAN1特异性抗体(货号abXXX, ABC公司)进行心肌细胞蛋白检测，发现RCAN1通过抑制钙调磷酸酶(calcineurin)信号通路，负向调控病理性心脏肥大的发展。
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以上文献示例聚焦于RCAN1抗体在疾病机制研究中的应用场景，如需真实文献，建议通过PubMed或Web of Science检索具体抗体货号(如Sigma-Aldrich的HPA016986或Santa Cruz的sc-XXXX)关联的研究。
**Background of RCAN1 Antibody**
The RCAN1 (Regulator of Calcineurin 1) protein, encoded by the *RCAN1* gene, is a critical regulator of calcineurin, a calcium-dependent phosphatase involved in numerous cellular processes, including immune response, apoptosis, and synaptic plasticity. RCAN1 modulates calcineurin activity by either inhibiting or facilitating its function, depending on cellular context and isoform expression. Two major isoforms, RCAN1-1 and RCAN1-4. are produced through alternative splicing, with RCAN1-1 being stress-inducible and implicated in neurodegenerative disorders, while RCAN1-4 is constitutively expressed and linked to developmental processes.
RCAN1 antibodies are essential tools for studying the protein's expression, localization, and role in diseases. Dysregulation of RCAN1 has been associated with Down syndrome (due to its location on chromosome 21), Alzheimer’s disease (via calcineurin-mediated Tau phosphorylation), and cardiovascular conditions. Researchers utilize RCAN1 antibodies in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to explore its involvement in calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathways. These antibodies also aid in understanding RCAN1's dual role as a tumor suppressor or promoter in various cancers.
Commercial RCAN1 antibodies are typically developed in rabbits or mice, targeting specific epitopes or isoforms. Validation includes testing for cross-reactivity and specificity across human, mouse, and rat samples. As RCAN1's functional complexity grows, its antibodies remain vital for elucidating its pathophysiological mechanisms and therapeutic potential.
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