| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MYSB; CAVB2; CACNLB2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CACNB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CACNB2抗体的3篇参考文献，按研究内容整理：
1. **文献名称**：*CACNB2 encodes the voltage-gated calcium channel β2 subunit in human heart: Functional characterization and disease-associated variants*
**作者**：Wang Q. et al.
**摘要**：研究通过Western blot和免疫组化验证了抗CACNB2抗体的特异性，发现其在小鼠和人心肌组织中高表达，并揭示了β2亚基突变与心律失常的关联。
2. **文献名称**：*Neuronal distribution and functional implications of CACNB2 in the mammalian brain*
**作者**：Chen J. et al.
**摘要**：利用CACNB2特异性抗体进行免疫荧光染色，发现其在海马和前额叶皮层神经元中富集，提示β2亚基可能通过调节钙通道活性影响突触可塑性。
3. **文献名称**：*Antibody-based profiling of CACNB2 isoforms in human tissues reveals differential expression patterns*
**作者**：Li H. et al.
**摘要**：开发并验证了针对不同CACNB2剪接变体的抗体，发现其在心脏、大脑和胰腺中的差异表达，为研究组织特异性功能提供工具。
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**备注**：以上文献为示例，实际发表情况需通过数据库(如PubMed)核实。建议结合关键词“CACNB2 antibody validation”或“CACNB2 immunolocalization”检索最新研究。
The CACNB2 antibody is designed to target the β2 subunit of voltage-gated calcium channels (VGCCs), which play a critical role in regulating calcium ion influx into excitable cells, influencing processes like muscle contraction, neurotransmitter release, and gene expression. The CACNB2 gene encodes the β2 subunit, a cytoplasmic auxiliary protein essential for the trafficking, membrane localization, and functional modulation of the pore-forming α1 subunit of L-type calcium channels (CaV1.2). These channels are particularly abundant in the heart, brain, and smooth muscle.
CACNB2 antibodies are widely used in research to study the expression, distribution, and molecular interactions of the β2 subunit in physiological and pathological contexts. Dysregulation or mutations in CACNB2 have been linked to cardiovascular disorders (e.g., Brugada syndrome, arrhythmias), neurological conditions (e.g., autism, schizophrenia), and metabolic syndromes. Researchers employ these antibodies in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate channelopathies or assess therapeutic interventions targeting calcium signaling.
Additionally, CACNB2 antibodies aid in exploring the subunit’s role in modulating channel kinetics and its interaction with other regulatory proteins. Their application extends to drug discovery, particularly in developing treatments for hypertension, heart failure, and neurological diseases. The antibody’s specificity and validation across species (e.g., human, mouse, rat) make it a vital tool for dissecting calcium channel biology and associated diseases.
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