| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | ik3-2; C20orf150; dJ908M14.2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CABLES2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CABLES2抗体的示例参考文献(均为假设性示例，具体文献请通过学术数据库检索)：
1. **文献名称**：*CABLES2 regulates cell cycle progression in colorectal cancer via CDK2 interaction*
**作者**：Smith A, et al.
**摘要**：研究通过CABLES2抗体进行免疫沉淀和Western blot分析，揭示了CABLES2通过结合CDK2抑制结直肠癌细胞周期进程的机制。
2. **文献名称**：*Development and validation of a monoclonal antibody for CABLES2 protein detection*
**作者**：Chen L, et al.
**摘要**：描述了针对CABLES2蛋白的小鼠单克隆抗体的开发，验证其在免疫组化(IHC)和流式细胞术中的应用，证实其在多种组织中的特异性表达。
3. **文献名称**：*CABLES2 expression correlates with prognosis in hepatocellular carcinoma*
**作者**：Wang Y, et al.
**摘要**：利用CABLES2抗体对肝癌组织进行染色，发现其低表达与患者预后不良相关，提示CABLES2可能作为潜在生物标志物。
4. **文献名称**：*Functional analysis of CABLES2 in neuronal development using CRISPR and antibody-based approaches*
**作者**：Kim T, et al.
**摘要**：结合CRISPR基因编辑和CABLES2抗体的免疫荧光技术，证明CABLES2在神经元分化过程中调控Wnt/β-catenin信号通路。
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**建议**：实际文献可通过PubMed、Google Scholar等平台搜索关键词“CABLES2 antibody”、“CABLES2 function”或“CABLES2 + [疾病/通路名称]”获取。注意筛选近年研究以获更新信息。
The CABLES2 antibody is designed to detect CABLES2 (Cdk5 and Abl enzyme substrate 2), a protein implicated in regulating cell cycle progression and cellular proliferation. CABLES2 interacts with cyclin-dependent kinases (CDKs), such as CDK1 and CDK2. and other kinases, influencing key checkpoints like the G1/S phase transition. This protein contains conserved structural domains that mediate kinase interactions, potentially modulating their activity and downstream signaling. Researchers employ the CABLES2 antibody in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and functional roles in both normal and pathological contexts.
CABLES2 has been linked to cancer biology, with studies suggesting it may act as a tumor suppressor. Altered CABLS2 expression has been observed in certain malignancies, correlating with disease progression or therapeutic responses. The antibody is often validated for reactivity in human, mouse, and rat samples, facilitating cross-species studies. Its applications extend to exploring cell cycle dysregulation, apoptosis, and differentiation mechanisms, particularly in oncology research. By enabling precise detection of CABLS2 in diverse experimental models, this tool supports efforts to unravel its biological significance and therapeutic potential in diseases marked by uncontrolled proliferation.
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