| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CANPMR |
| WB Predicted band size | 184 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CAMTA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CAMTA1抗体的3篇示例参考文献(注：以下内容为虚构示例，仅用于演示格式)：
1. **文献名称**: *CAMTA1 as a Novel Immunohistochemical Marker for Epithelioid Hemangioendothelioma*
**作者**: Antonescu CR, et al.
**摘要**: 本研究验证了CAMTA1抗体在区分上皮样血管内皮瘤与其他软组织肿瘤中的特异性，通过免疫组化分析证实了CAMTA1在肿瘤细胞核中的高表达，支持其作为诊断标志物的价值。
2. **文献名称**: *Expression and Prognostic Significance of CAMTA1 in Pediatric Gliomas*
**作者**: Smith JL, et al.
**摘要**: 利用CAMTA1抗体检测儿童脑胶质瘤样本，发现其低表达与肿瘤侵袭性和不良预后显著相关，提示CAMTA1可能参与胶质瘤的抑癌通路调控。
3. **文献名称**: *CAMTA1 Antibody-Based Detection in Fusion-Driven Sarcomas*
**作者**: Yoshida A, et al.
**摘要**: 研究采用CAMTA1抗体对多种肉瘤进行筛查，揭示了其在特定融合基因阳性的圆细胞肉瘤中的敏感性，为分子分型提供了辅助诊断依据。
如需真实文献，建议通过PubMed或Google Scholar检索关键词“CAMTA1 antibody”、“CAMTA1 immunohistochemistry”。
The CAMTA1 (calmodulin-binding transcription activator 1) antibody is a tool used to detect the presence and localization of the CAMTA1 protein, a transcription factor involved in regulating gene expression related to cellular growth, stress responses, and tumor suppression. CAMTA1 contains conserved domains, including a CG-1 DNA-binding domain, TIG helicase-like domain, and calmodulin-binding motifs, enabling calcium/calmodulin-dependent transcriptional regulation. It is broadly expressed in the brain, heart, and muscle tissues.
CAMTA1 has gained attention in oncology due to its role in specific cancers. Chromosomal rearrangements involving the CAMTA1 gene (e.g., WWTR1::CAMTA1 fusion) are hallmark genetic alterations in epithelioid hemangioendothelioma, a rare vascular tumor. Additionally, CAMTA1 expression is linked to favorable prognosis in certain brain tumors, such as astrocytomas. Antibodies against CAMTA1 are critical in immunohistochemistry (IHC) to diagnose and differentiate these tumors from histological mimics.
In research, CAMTA1 antibodies are utilized in Western blotting, immunofluorescence, and IHC to study its regulatory mechanisms in cell cycle control, apoptosis, and neural development. Commercially available clones (e.g., EPR12835. D3G8I) vary in specificity across species and applications. Validation in appropriate controls is essential, as cross-reactivity or nonspecific staining may occur. Overall, CAMTA1 antibodies serve as valuable reagents in both diagnostic pathology and molecular research, bridging molecular alterations with clinical outcomes.
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