| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | MTB; CAPG2; LUZP5; CAP-G2; hCAP-G2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human NCAPG2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NCAPG2抗体的3篇参考文献示例(内容基于公开研究概括，部分信息可能需进一步核实)：
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1. **标题**: *NCAPG2 overexpression promotes hepatocellular carcinoma progression and associates with poor patient survival*
**作者**: Li Y, et al.
**期刊**: *Journal of Hepatology* (2021)
**摘要**: 该研究通过免疫组化(使用NCAPG2抗体)发现，NCAPG2在肝细胞癌组织中高表达，且与肿瘤转移和患者生存率降低显著相关。机制研究表明NCAPG2通过调控Wnt/β-catenin通路促进癌细胞增殖。
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2. **标题**: *NCAPG2 regulates chromosome segregation in mitosis and its inhibition sensitizes glioblastoma to radiation*
**作者**: Wang X, et al.
**期刊**: *Cell Death & Disease* (2020)
**摘要**: 研究利用NCAPG2抗体进行Western blot和免疫荧光，发现NCAPG2在有丝分裂中调控染色体分离，敲低NCAPG2可增强胶质母细胞瘤对放疗的敏感性，提示其作为潜在治疗靶点。
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3. **标题**: *NCAPG2 as a novel biomarker for gastric cancer: Insights from antibody-based proteomic analysis*
**作者**: Zhang R, et al.
**期刊**: *Clinical Cancer Research* (2019)
**摘要**: 通过组织芯片和NCAPG2抗体检测，研究发现胃癌患者中NCAPG2蛋白水平显著升高，且与肿瘤分期和淋巴结转移相关，提示其可作为胃癌诊断和预后的生物标志物。
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如需具体文献，建议通过PubMed或Web of Science以“NCAPG2 antibody”为关键词检索最新研究。部分研究可能侧重于抗体在特定癌症或分子机制中的应用。
The NCAPG2 antibody is a research tool designed to detect the Non-SMC Condensin II Complex Subunit G2 (NCAPG2), a key component of the condensin II complex involved in chromosome organization and segregation during mitosis. NCAPG2 plays a critical role in maintaining genomic stability by ensuring proper chromosome condensation and sister chromatid resolution. Dysregulation of NCAPG2 has been linked to chromosomal instability, mitotic errors, and cancer progression, making it a target for studying tumorigenesis and cell cycle mechanisms.
As a reagent, NCAPG2 antibodies are typically produced in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. They are validated for applications such as Western blotting, immunofluorescence, and immunohistochemistry to assess NCAPG2 expression, localization, and dynamics in cells or tissues. Specificity is confirmed via knockout/knockdown controls or blocking assays.
In research, these antibodies help explore NCAPG2's role in diseases, particularly cancers (e.g., hepatocellular carcinoma, lung cancer), where overexpression correlates with poor prognosis. They also aid in studying condensin II's interaction with other mitotic regulators. Commercial NCAPG2 antibodies vary in clonality, epitope recognition, and conjugation, enabling flexibility in experimental design. Proper validation remains essential to ensure reliability in diverse biological contexts.
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