| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | KV6.3; KV6.4 |
| WB Predicted band size | 59 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human KCNG4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KCNG4抗体的3篇示例文献(内容为模拟概括，仅供参考)：
1. **文献名称**: "Characterization of a novel antibody targeting the potassium channel subunit KCNG4 in neural tissues"
**作者**: Smith A, et al.
**摘要**: 研究报道了一种特异性识别KCNG4(Kv6.4)通道蛋白的单克隆抗体，验证了其在哺乳动物脑组织中的表达定位，并发现其与神经元兴奋性调节相关。
2. **文献名称**: "KCNG4 antibody reveals distinct expression patterns in cardiac and smooth muscle cells"
**作者**: Lee J, et al.
**摘要**: 通过免疫组化和Western blot分析，证实KCNG4抗体可特异性标记心脏和血管平滑肌细胞中的通道蛋白，提示KCNG4可能参与心血管系统的电生理调控。
3. **文献名称**: "Development and validation of a polyclonal anti-KCNG4 antibody for functional studies in heterologous expression systems"
**作者**: Gonzalez R, et al.
**摘要**: 开发了一种兔源多克隆抗体，验证了其在HEK293细胞中外源性表达KCNG4蛋白的检测能力，并用于研究该通道与其它钾通道亚基的相互作用机制。
**注意**：以上文献为模拟示例，实际研究中建议通过PubMed或Google Scholar等平台检索具体文献。
The KCNG4 antibody is a tool used to study the potassium voltage-gated channel subfamily G member 4 (KCNG4), a protein encoded by the *KCNG4* gene. KCNG4 belongs to the voltage-gated potassium (Kv) channel family, specifically the Kv6 subfamily, and functions as a regulatory subunit. These channels play critical roles in maintaining cellular excitability by modulating potassium ion flow across membranes, influencing action potential repolarization and electrical signaling in excitable cells like neurons and muscle cells. Unlike pore-forming α-subunits, KCNG4 cannot form functional channels alone but interacts with other Kv α-subunits (e.g., Kv2.1) to alter their gating kinetics, expression, or trafficking.
Research on KCNG4 is limited compared to other Kv channels, but emerging studies suggest its involvement in neurological and cardiovascular functions. Dysregulation of Kv channels has been linked to conditions such as epilepsy, arrhythmias, and cancer, positioning KCNG4 as a potential biomarker or therapeutic target. Antibodies against KCNG4 enable detection of its expression and localization in tissues, aiding investigations into its physiological roles and disease associations. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Despite its understudied status, KCNG4's interaction with major Kv channels underscores its importance in cellular electrophysiology, driving interest in further characterizing its mechanisms and therapeutic relevance.
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