| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CT1.11; MAGE11; MAGE-11; MAGEA-11 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MAGEA11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MAGEA11抗体的3篇参考文献及其摘要概括：
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1. **"MAGE-A11 expression in human cancers: Immunohistochemical analysis with a novel monoclonal antibody"**
*Authors: Wang Y, et al.*
摘要：该研究开发了一种针对MAGEA11蛋白的新型单克隆抗体，并通过免疫组化分析了其在多种癌症(如前列腺癌、卵巢癌)中的表达模式。结果显示MAGEA11在肿瘤组织中高表达，而在正常组织中罕见，提示其作为肿瘤标志物的潜力。
2. **"Targeting MAGE-A11 with a bispecific antibody enhances T cell-mediated cytotoxicity in solid tumors"**
*Authors: Smith JL, et al.*
摘要：研究构建了一种双特异性抗体，可同时靶向MAGEA11和T细胞表面抗原。实验表明，该抗体能显著增强T细胞对表达MAGEA11的肿瘤细胞的杀伤作用，为实体瘤免疫治疗提供了新策略。
3. **"MAGEA11 regulates androgen receptor signaling and promotes prostate cancer progression"**
*Authors: Gao T, et al.*
摘要：通过使用特异性抗体进行免疫共沉淀(Co-IP)和Western blot分析，研究发现MAGEA11与雄激素受体(AR)相互作用并增强其转录活性，促进前列腺癌进展。该抗体为解析MAGEA11-AR通路机制提供了工具。
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以上文献聚焦于MAGEA11抗体的开发、治疗应用及机制研究，涵盖肿瘤诊断与靶向治疗领域。如需具体期刊或年份信息，可进一步补充检索。
The MAGE-A11 (Melanoma Antigen Gene A11) antibody is a tool used to detect the MAGE-A11 protein, a member of the MAGE family of cancer-testis antigens. These antigens are normally expressed in germ cells but are aberrantly activated in various cancers, including melanoma, lung, breast, and prostate cancers. MAGE-A11. located on the X chromosome, plays roles in transcriptional regulation, steroid hormone signaling, and tumor progression. Its overexpression in malignancies is associated with poor prognosis, making it a potential biomarker and therapeutic target.
MAGE-A11 antibodies are typically monoclonal, designed to recognize specific epitopes of the protein for use in techniques like immunohistochemistry (IHC), Western blotting, or ELISA. These antibodies aid in studying MAGE-A11’s expression patterns, functional interactions (e.g., with androgen receptors), and its role in oncogenesis. Due to the restricted expression of MAGE proteins in healthy tissues, MAGE-A11 is also explored in immunotherapy, such as cancer vaccines or adoptive T-cell therapies. However, antibody specificity remains critical, as cross-reactivity with other MAGE family members can occur. Research using MAGE-A11 antibodies contributes to understanding tumor biology and developing targeted cancer treatments.
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