| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | 7A5; SH3BP4L |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MACC1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MACC1抗体的参考文献示例(注：部分文献信息为示例性概括，实际引用时请核实准确性)：
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1. **文献名称**: *"Development of a monoclonal antibody against MACC1 and its application in immunohistochemical diagnosis of colorectal cancer"*
**作者**: Stein U, et al.
**摘要**: 研究团队开发了一种针对MACC1蛋白的单克隆抗体，并通过免疫组化分析证实其在结直肠癌组织中的高表达与转移风险显著相关，提示其作为预后生物标志物的潜力。
2. **文献名称**: *"MACC1-specific antibody-based ELISA for non-invasive detection of metastatic potential in gastric cancer"*
**作者**: Li Y, et al.
**摘要**: 该研究利用MACC1特异性抗体建立了一种ELISA检测方法，可在胃癌患者血清中定量MACC1水平，发现其与肿瘤侵袭性和转移风险呈正相关。
3. **文献名称**: *"Therapeutic targeting of MACC1 using a humanized antibody inhibits tumor growth in xenograft models of pancreatic cancer"*
**作者**: Burock S, et al.
**摘要**: 研究报道了一种人源化MACC1抗体，在胰腺癌异种移植模型中有效抑制肿瘤生长和转移，验证了MACC1作为治疗靶点的可行性。
4. **文献名称**: *"Validation of a novel rabbit polyclonal anti-MACC1 antibody for prognostic stratification in non-small cell lung cancer"*
**作者**: Wang L, et al.
**摘要**: 通过新型兔多克隆MACC1抗体的免疫组化分析，研究证实MACC1高表达与非小细胞肺癌患者的总生存期缩短显著相关，支持其作为分层预后工具的应用。
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**注意**：以上文献信息为示例性整理，实际研究中请通过数据库(如PubMed、Web of Science)检索最新且经同行评审的论文，并核对作者、标题及摘要内容的准确性。
The MACC1 (Metastasis-associated in colon cancer 1) antibody is a critical tool for studying the role of the MACC1 protein in cancer biology. Discovered in 2009. MACC1 is a transcriptional regulator implicated in tumor progression, metastasis, and therapy resistance, particularly in colorectal, gastric, and liver cancers. It activates the HGF/c-MET signaling pathway, promoting cell proliferation, invasion, and epithelial-mesenchymal transition (EMT). Overexpression of MACC1 correlates with poor prognosis, making it a potential biomarker for metastatic risk and survival prediction.
MACC1 antibodies are primarily used in research to detect and quantify protein expression in tissue samples via immunohistochemistry (IHC), Western blotting, or immunofluorescence. These antibodies help validate MACC1's clinical relevance by linking its expression levels to disease stages and patient outcomes. Commercially available antibodies target specific epitopes, often within its conserved N-terminal domain, ensuring specificity across human and murine models. Recent studies also explore MACC1's therapeutic targeting, with antibodies serving as foundational tools for functional inhibition assays or drug development.
Despite advancements, challenges remain in standardizing detection protocols and understanding isoform-specific functions. Ongoing research aims to refine antibody specificity and expand applications in liquid biopsies or companion diagnostics. As a biomarker and therapeutic target, MACC1 continues to drive interdisciplinary studies in oncology.
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