| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | LOXL |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human LOXL3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LOXL3抗体的3篇参考文献的简要总结(文献信息为示例性质，非真实引用)：
1. **标题**：LOXL3在结直肠癌中的表达及临床意义
**作者**：Smith A et al.
**摘要**：研究通过Western blot和免疫组化(使用LOXL3特异性抗体)发现，LOXL3在结直肠癌组织中高表达，并与患者预后不良相关，提示其可能作为肿瘤标志物。
2. **标题**：LOXL3调控TGF-β信号通路促进肺纤维化
**作者**：Zhang Y et al.
**摘要**：利用LOXL3抗体进行免疫沉淀和细胞定位分析，发现LOXL3通过激活TGF-β通路增强成纤维细胞分化，为肺纤维化治疗提供潜在靶点。
3. **标题**：LOXL3基因敲除小鼠模型揭示其在胚胎发育中的作用
**作者**：Lee H et al.
**摘要**：研究通过LOXL3抗体检测发现，LOXL3缺失导致小鼠胚胎心脏发育异常，表明其在细胞外基质重塑中的关键作用。
4. **标题**：LOXL3与黑色素瘤转移的分子机制研究
**作者**：Garcia-Rojas M et al.
**摘要**：采用LOXL3抗体进行组织芯片分析，发现LOXL3通过调控EMT过程促进黑色素瘤侵袭转移，为靶向治疗提供依据。
(注：以上内容为模拟学术文献描述，实际研究中需查询具体数据库如PubMed获取真实文献。)
Lysyl oxidase-like 3 (LOXL3) is a member of the lysyl oxidase (LOX) family, which comprises copper-dependent enzymes critical for extracellular matrix (ECM) remodeling. These enzymes catalyze the cross-linking of collagen and elastin by oxidizing lysine residues, thereby maintaining tissue integrity and biomechanical properties. LOXL3 shares structural homology with other LOX family members but exhibits distinct expression patterns and functional roles. It is broadly expressed in various tissues, including the heart, lungs, and reproductive organs, and plays roles in embryonic development, connective tissue homeostasis, and cellular differentiation. Beyond its canonical enzymatic activity, LOXL3 has been implicated in transcriptional regulation, apoptosis, and epithelial-mesenchymal transition (EMT), linking it to cancer progression, fibrosis, and metabolic disorders.
LOXL3 antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence to investigate LOXL3's tissue-specific roles. Dysregulation of LOXL3 has been observed in cancers (e.g., melanoma, gastric, and breast cancer), where it may promote metastasis, angiogenesis, and therapy resistance. Antibodies targeting LOXL3 also aid in exploring its non-enzymatic functions, such as modulating signaling pathways (e.g., TGF-β, Notch) or interacting with transcription factors. Additionally, LOXL3 antibodies hold potential for therapeutic development, as inhibiting LOXL3 could suppress pathological ECM remodeling in fibrotic diseases or tumor microenvironments. Ongoing research aims to clarify its dual roles in tissue repair versus disease progression, emphasizing the need for reliable antibody tools.
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