Rabbit Polyclonal LLGL2 Antibody

The LLGL2 (Lethal giant larvae homolog 2) antibody is a tool used to study the LLGL2 protein, a key player in cell polarity regulation. LLGL2 belongs to the Scribble complex, which governs asymmetric cell division, epithelial polarity, and tissue organization. It is the mammalian ortholog of Drosophila Lgl, originally identified in fruit flies for its tumor-suppressor role in larval development. LLGL2 interacts with PAR (Partitioning defective) proteins and cytoskeletal components to maintain apical-basal polarity in epithelial cells, critical for cell adhesion, migration, and differentiation. Dysregulation of LLGL2 is implicated in cancers, including breast cancer and glioblastoma, where its expression may vary depending on tumor type and context. Some studies suggest LLGL2 acts as a tumor suppressor by inhibiting proliferation, while others propose pro-oncogenic roles in metastasis. The antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect LLGL2 localization and expression levels. Challenges include distinguishing between LLGL2 isoforms (e.g., LLGL2-67 and LLGL2-70) and resolving conflicting functional data across studies. Recent research explores its role in neuronal development and synaptic plasticity. Validation of antibody specificity, often via knockout controls, remains crucial due to homology with LLGL1 and isoform diversity.