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Rabbit Polyclonal LLGL1 Antibody

  • 中文名: LLGL1抗体
  • 别    名: DLG4; HUGL; LLGL; HUGL1; HUGL-1
货号: IPDX11906
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesDLG4; HUGL; LLGL; HUGL1; HUGL-1
WB Predicted band size115 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human LLGL1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇关于LLGL1抗体的参考文献概览(基于模拟生成,非真实文献):

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1. **文献名称**: "LLGL1 regulates cell polarity and tumorigenesis through tight junction stabilization"

**作者**: Smith A, et al.

**摘要**: 研究揭示了LLGL1通过稳定上皮细胞紧密连接维持细胞极性,其缺失导致细胞极性紊乱并促进乳腺癌细胞的侵袭转移,抗体实验用于定位LLGL1在细胞连接处的表达。

2. **文献名称**: "Loss of LLGL1 expression correlates with poor prognosis in colorectal cancer"

**作者**: Chen L, et al.

**摘要**: 通过免疫组化(LLGL1抗体)分析结直肠癌组织,发现LLGL1低表达与肿瘤分期和患者生存率显著相关,提示其作为肿瘤抑制因子的潜在临床价值。

3. **文献名称**: "LLGL1 mediates asymmetric division of neural stem cells via interaction with PAR3/PAR6 complex"

**作者**: Tanaka Y, et al.

**摘要**: 研究利用LLGL1抗体阻断实验,证明LLGL1通过与PAR复合物互作调控神经干细胞不对称分裂,影响神经发育和分化过程。

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(注:以上文献为示例性质,实际研究中请通过PubMed、Google Scholar等平台检索真实文献。)

背景信息

The LLGL1 (Lethal(2) giant larvae 1) antibody is a tool used to study the LLGL1 protein, a conserved cell polarity regulator encoded by the *LLGL1* gene in humans. First identified in *Drosophila* as a tumor suppressor, mammalian LLGL1 plays critical roles in asymmetric cell division, epithelial cell polarity, and cell migration by interacting with other polarity proteins like PAR3 and aPKC. It acts as a scaffolding protein, facilitating the formation of multiprotein complexes essential for maintaining tissue architecture. Dysregulation of LLGL1 is linked to cancer progression, particularly in breast, ovarian, and colorectal tumors, where its loss or mislocalization promotes epithelial-mesenchymal transition (EMT) and metastasis. The LLGL1 antibody is widely employed in research to detect protein expression, localization, and post-translational modifications via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Studies using this antibody have revealed its phosphorylation-dependent inactivation during EMT and its potential as a prognostic biomarker. Commercial LLGL1 antibodies are typically validated for specificity against human, mouse, or rat samples, enabling cross-species comparative analyses. Ongoing research focuses on elucidating LLGL1's role in mechanotransduction, neuronal development, and therapeutic resistance, underscoring its broad relevance in cell biology and oncology.

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