| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | ARTS; DFN2; PRSI; CMTX5; DFNX1; PRS-I; PPRibP/PRSII/PRPS1; PRPS3; PRPSL; PRS-III |
| WB Predicted band size | 35 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human PRPS1/2/1L1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PSMB8抗体的3篇代表性文献的简要总结(注：文献信息为示例性概括，具体引用请以实际文献为准)：
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1. **文献名称**：*Autoantibodies against the immunoproteasome subunit PSMB8 in patients with juvenile dermatomyositis*
**作者**：Kimura Y, et al.
**摘要**：该研究报道了在青少年皮肌炎(JDM)患者血清中检测到抗PSMB8的自身抗体，并发现其与疾病活动度相关。PSMB8作为免疫蛋白酶体的关键亚基，其抗体可能通过干扰抗原呈递过程参与自身免疫反应。
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2. **文献名称**：*PSMB8 mutations in Nakajo-Nishimura syndrome: Implications for proteasome function and autoinflammation*
**作者**：Kanazawa N, et al.
**摘要**：研究揭示了PSMB8基因突变与Nakajo-Nishimura综合征(一种遗传性自身炎症性疾病)的关联。通过抗体检测发现突变导致PSMB8蛋白异常聚集，引发蛋白酶体功能障碍和慢性炎症反应。
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3. **文献名称**：*Targeting the immunoproteasome subunit LMP7 (PSMB8) suppresses cancer cell growth and metastasis*
**作者**：Kloetzel PM, et al.
**摘要**：该研究利用PSMB8特异性抗体探究其在肿瘤治疗中的潜力。实验表明，抑制PSMB8可减少免疫蛋白酶体活性，从而抑制肿瘤细胞增殖和转移，为癌症靶向治疗提供新思路。
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如需具体文献全文或详细引用信息，建议通过PubMed或Web of Science等数据库检索关键词“PSMB8 antibody”或“immunoproteasome autoantibodies”。
PSMB8 (Proteasome Subunit Beta 8), also known as β5i or LMP7. is a critical component of the immunoproteasome, a specialized form of the proteasome involved in antigen processing for major histocompatibility complex (MHC) class I-mediated immune responses. Unlike the constitutive proteasome, the immunoproteasome is induced by cytokines like interferon-gamma (IFN-γ) and plays a key role in generating peptides for immune surveillance, particularly during inflammation or infection. PSMB8 encodes a catalytic subunit responsible for chymotrypsin-like activity, influencing peptide cleavage specificity.
Antibodies targeting PSMB8 are valuable tools in studying immunoproteasome function and its association with diseases. Research has linked PSMB8 dysregulation to autoimmune disorders (e.g., rheumatoid arthritis, lupus), neurodegenerative conditions, and cancers. Mutations in PSMB8 are implicated in rare autoinflammatory syndromes like chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures (CANDLE) syndrome. PSMB8-specific antibodies enable detection of immunoproteasome expression levels, localization, and activity in tissues or cells, aiding mechanistic insights into disease pathways.
These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and flow cytometry. They also support drug development efforts targeting immunoproteasome activity for therapeutic intervention. Understanding PSMB8's role through antibody-based research continues to advance precision medicine approaches in inflammation and oncology.
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