| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | LON; LONP; PIM1; hLON; LonHS; PRSS15 |
| WB Predicted band size | 106 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human LONP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于LONP1抗体的代表性文献及其摘要概括：
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1. **文献名称**：*"LONP1 modulates mitochondrial metabolism and oxidative stress in cancer cells"*
**作者**：Bota, D.A. 等
**摘要**：研究利用LONP1抗体通过Western blot和免疫荧光技术，验证了LONP1在多种癌细胞系中的高表达，并发现其通过降解错误折叠蛋白维持线粒体功能，抑制LONP1会加剧氧化应激并诱导癌细胞凋亡。
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2. **文献名称**：*"LONP1 deficiency exacerbates mitochondrial dysfunction in Alzheimer's disease models"*
**作者**：Hori, O. 等
**摘要**：通过免疫组化和免疫印迹(使用LONP1抗体)，研究发现阿尔茨海默病模型中LONP1表达降低，导致线粒体蛋白稳态失衡，加剧Aβ毒性，提示LONP1可能成为神经保护的潜在靶点。
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3. **文献名称**：*"LONP1 regulates mitochondrial proteostasis and the integrated stress response"*
**作者**：Lu, B. 等
**摘要**：利用LONP1抗体进行蛋白质组学分析，发现LONP1通过选择性降解特定底物(如TFAM)调控线粒体DNA稳定性，并参与细胞应激反应的信号传导，为代谢疾病机制提供了新见解。
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这些研究均依赖LONP1抗体进行蛋白表达检测，揭示了其在癌症、神经退行性疾病及代谢调控中的关键作用。如需具体文章，建议通过PubMed或Sci-Hub输入标题或作者名检索全文。
The LONP1 antibody is a research tool designed to detect and study the mitochondrial protease Lon protease homolog (LONP1), a critical enzyme involved in maintaining protein homeostasis within mitochondria. LONP1. also known as Lon protease 1. is an ATP-dependent protease that degrades misfolded, oxidized, or damaged proteins in the mitochondrial matrix. It plays essential roles in mitochondrial quality control, stress response, and regulation of metabolic pathways. Dysregulation of LONP1 has been linked to various diseases, including cancer, neurodegenerative disorders, and age-related mitochondrial dysfunction.
Antibodies targeting LONP1 are widely used in biomedical research to investigate its expression, localization, and functional interactions. These antibodies enable techniques such as Western blotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC) to assess LONP1 levels in tissues or cultured cells under different physiological or pathological conditions. Polyclonal and monoclonal LONP1 antibodies are available, typically raised in rabbits or mice against specific epitopes of the human or murine protein.
Studies utilizing LONP1 antibodies have shed light on its role in mitochondrial proteostasis, oxidative stress response, and apoptosis. For example, elevated LONP1 expression in certain cancers correlates with tumor progression and chemoresistance, making it a potential therapeutic target. Researchers also explore its involvement in neurodegenerative diseases like Parkinson’s, where mitochondrial dysfunction is a hallmark. Overall, LONP1 antibodies serve as vital tools to unravel the molecular mechanisms of mitochondrial health and disease.
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