| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| WB Predicted band size | 68 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human IVL |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IVL(Involucrin)抗体的3篇虚构示例参考文献，供参考(实际文献请通过PubMed、Google Scholar等平台获取)：
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1. **标题**: *Involucrin Antibody as a Marker for Epidermal Differentiation in Psoriasis*
**作者**: Smith A, et al.
**摘要**: 本研究利用IVL抗体通过免疫组化分析银屑病患者皮肤样本，发现IVL表达异常与角质形成细胞分化缺陷相关，提示其在疾病病理机制中的作用。
2. **标题**: *Role of Involucrin in Cutaneous Squamous Cell Carcinoma: Insights from IVL Knockout Models*
**作者**: Chen L, et al.
**摘要**: 通过构建IVL基因敲除小鼠模型，结合IVL抗体检测，发现IVL缺失导致表皮屏障功能受损，并促进皮肤鳞状细胞癌的早期发展。
3. **标题**: *Development of a Novel Monoclonal IVL Antibody for Diagnostic Applications*
**作者**: Tanaka K, et al.
**摘要**: 文章报道了一种高特异性IVL单克隆抗体的开发，验证了其在鉴别表皮分化异常疾病(如鱼鳞病)中的潜在临床诊断价值。
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**注意**：以上文献为示例，非真实存在。建议通过学术数据库检索关键词“Involucrin antibody”“epidermal differentiation”等获取真实研究。
Involucrin (IVL) is a key structural protein in the epidermis, primarily expressed in the suprabasal layers of stratified squamous epithelia. It plays a critical role in the formation of the cornified cell envelope, a protective barrier essential for skin integrity and defense against environmental stressors. IVL is synthesized during terminal differentiation of keratinocytes and cross-linked by transglutaminases to other proteins (e.g., loricrin, small proline-rich proteins), contributing to epidermal resilience and permeability regulation.
IVL antibodies are immunological tools targeting this protein, widely used in dermatological research and diagnostics. They help investigate epidermal differentiation disorders, such as psoriasis, ichthyosis, and skin cancers, where IVL expression is often dysregulated. In research, IVL antibodies are employed in techniques like immunohistochemistry, Western blotting, and immunofluorescence to study keratinocyte maturation, tissue-specific protein localization, and disease mechanisms. Clinically, they aid in diagnosing skin pathologies by identifying abnormal IVL expression patterns in biopsies.
Recent studies also explore IVL's potential as a biomarker in precancerous lesions and squamous cell carcinoma. However, cross-reactivity with related proteins remains a challenge, necessitating careful validation. Overall, IVL antibodies are pivotal in advancing understanding of epidermal biology and developing targeted therapies for skin diseases.
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