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Rabbit Polyclonal PPP1CC Antibody

  • 中文名: PPP1CC抗体
  • 别    名: PP1C; PP-1G; PPP1G
货号: IPDX12072
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是3篇与 **PPP1CC抗体** 相关的参考文献,包含文献名称、作者及简要摘要:

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1. **文献名称**: *"PPP1CC2 is essential for testicular function and sperm morphogenesis in mice"*

**作者**: Varmuza S, et al.

**摘要**: 本研究通过基因敲除小鼠模型,揭示了PPP1CC2亚型在精子发生中的关键作用。利用特异性PPP1CC抗体进行免疫组化和Western blot分析,发现PPP1CC2缺失导致精子头部畸形和生育力下降,表明其在精子形态发生中不可或缺。

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2. **文献名称**: *"Protein phosphatase 1 catalytic isoforms in mammalian cells: Substrate specificity and cellular regulation"*

**作者**: Heroes E, et al.

**摘要**: 文章系统分析了PPP1不同催化亚型(包括PPP1CC)的底物特异性和调控机制。通过特异性抗体区分PPP1CA、PPP1CB和PPP1CC亚型,发现PPP1CC在细胞周期调控中通过结合特定调节亚基发挥独特功能。

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3. **文献名称**: *"Altered expression of protein phosphatase 1 catalytic subunits is associated with late-stage lung cancer"*

**作者**: Li Y, et al.

**摘要**: 研究利用PPP1CC抗体对肺癌组织样本进行免疫组化分析,发现PPP1CC在晚期肺癌中表达显著下调,且低表达与患者预后不良相关,提示其可能作为肿瘤进展的生物标志物。

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4. **文献名称**: *"PPP1CC interacts with the SMN complex to regulate snRNP biogenesis"*

**作者**: Golembe TJ, et al.

**摘要**: 本文通过免疫共沉淀(Co-IP)结合PPP1CC抗体,发现PPP1CC与SMN复合物相互作用,调控snRNP的生物合成,为脊髓性肌萎缩症(SMA)的分子机制提供了新视角。

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以上研究均通过PPP1CC抗体进行蛋白定位、表达水平检测或互作分析,涵盖生殖生物学、癌症及神经疾病等领域。

背景信息

The PPP1CC antibody is a crucial tool in studying the PPP1CC protein, a gamma isoform of the catalytic subunit of protein phosphatase 1 (PP1). PP1 is a serine/threonine phosphatase involved in regulating diverse cellular processes, including cell cycle progression, signal transduction, and metabolism. The PPP1CC gene encodes two splice variants (PPP1CC1 and PPP1CC2) that differ in their C-terminal regions, influencing subcellular localization and interaction with regulatory proteins. PPP1CC antibodies are widely used to detect expression levels, tissue distribution, and post-translational modifications of PPP1CC in research models. These antibodies are essential for techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in understanding PPP1CC's role in spermatogenesis (where it is highly expressed in testes), cancer progression (via pathways like AKT and Wnt/β-catenin), and neurological disorders. Commercially available antibodies are typically raised in rabbits or mice against specific PPP1CC epitopes, with validation across human, mouse, and rat samples. Researchers also utilize these antibodies to investigate PP1's regulatory mechanisms through binding to targeting subunits (e.g., PPP1R) and its crosstalk with kinases in disease contexts.

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